2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Methionine sulfoxide

L-Methionine sulfoxide  (Synonyms: H-Met(O)-OH)

Cat. No.: HY-W010104 Purity: ≥98.0%
COA Handling Instructions

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L-Methionine sulfoxide (H-Met(O)-OH), a metabolite of Methionine, induces M1/classical macrophage polarization, and modulates oxidative stress and purinergic signaling parameters.

For research use only. We do not sell to patients.

L-Methionine sulfoxide Chemical Structure

L-Methionine sulfoxide Chemical Structure

CAS No. : 3226-65-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
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10 mM * 1 mL in Water USD 55 In-stock
Solid
500 mg USD 50 In-stock
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Methionine sulfoxide:

L-Methionine sulfoxide Related Antibodies

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Description

L-Methionine sulfoxide (H-Met(O)-OH), a metabolite of Methionine, induces M1/classical macrophage polarization, and modulates oxidative stress and purinergic signaling parameters[1].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

165.21

Formula

C5H11NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCS(C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (605.29 mM; Need ultrasonic)

DMSO : 1 mg/mL (6.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0529 mL 30.2645 mL 60.5290 mL
5 mM 1.2106 mL 6.0529 mL 12.1058 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (605.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (247 KB) HNMR (245 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.0529 mL 30.2645 mL 60.5290 mL 151.3226 mL
5 mM 1.2106 mL 6.0529 mL 12.1058 mL 30.2645 mL
H2O 10 mM 0.6053 mL 3.0265 mL 6.0529 mL 15.1323 mL
15 mM 0.4035 mL 2.0176 mL 4.0353 mL 10.0882 mL
20 mM 0.3026 mL 1.5132 mL 3.0265 mL 7.5661 mL
25 mM 0.2421 mL 1.2106 mL 2.4212 mL 6.0529 mL
30 mM 0.2018 mL 1.0088 mL 2.0176 mL 5.0441 mL
40 mM 0.1513 mL 0.7566 mL 1.5132 mL 3.7831 mL
50 mM 0.1211 mL 0.6053 mL 1.2106 mL 3.0265 mL
60 mM 0.1009 mL 0.5044 mL 1.0088 mL 2.5220 mL
80 mM 0.0757 mL 0.3783 mL 0.7566 mL 1.8915 mL
100 mM 0.0605 mL 0.3026 mL 0.6053 mL 1.5132 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Methionine sulfoxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Methionine sulfoxide3226-65-1H-Met(O)-OHEndogenous MetaboliteInhibitorinhibitorinhibit

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