L-Ornithine L-aspartate

Name: L-Ornithine L-aspartate
Brand: MedChemExpress
SKU: HY-A0282
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0282 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions.

For research use only. We do not sell to patients.

L-Ornithine L-aspartate Chemical Structure

CAS No. : 3230-94-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

L-Ornithine L-aspartate (5 mM, 24 h) increases the redox activity of mitochondria in SH-SY5Y cells, and counteracts ROT- and 6-OHDA- induced mitochondrial depolarization^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-Ornithine L-aspartate (300 mg/kg/h, i.v. infusions) prevents ammonia-precipitated coma in portal-systemic encephalopathy (PSE) rats^[2].
L-Ornithine L-aspartate (2 g/kg, p.o. for 10 days) protects Thioacetamide (HY-Y0698)-induced hepatic damage in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Thioacetamide (250 mg/kg, i.p. for 2 days) induced hepatopathy in rats^[3]
Dosage:	2 g/kg
Administration:	p.o. for 10 days
Result:	Restored hepatic architecture and lobular structure in rat liver sections (histological evaluation). Reduced levels of AST, ALT, ALKP, BRN, and tissue TBARS concentration.

Molecular Weight

265.26

Formula

C₉H₁₉N₃O₆

CAS No.

3230-94-2

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC(O)=O)C(O)=O.N[C@@H](CCCN)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (942.47 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7699 mL	18.8494 mL	37.6989 mL
5 mM	0.7540 mL	3.7699 mL	7.5398 mL
10 mM	0.3770 mL	1.8849 mL	3.7699 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (188.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (253 KB) HNMR (260 KB)

Handling Instructions (2659 KB)

References

[1]. Sikorska H, et al. [Physiological functions of L-ornithine and L-aspartate in the body and the efficacy of administration of L-ornithine-L-aspartate in conditions of relative deficiency]. Pol Merkur Lekarski. 2010 Jun;28(168):490-5. [Content Brief]

[2]. Rose C, et al. L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metab Brain Dis. 1998 Jun;13(2):147-57. [Content Brief]

[3]. Najmi AK, et al. Effect of l-ornithine l-aspartate against thioacetamide-induced hepatic damage in rats. Indian J Pharmacol. 2010 Dec;42(6):384-7. [Content Brief]

[4]. Sisalli MJ, et al. L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson's Disease Models. Cells. 2022 Sep 17;11(18):2909. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7699 mL	18.8494 mL	37.6989 mL	94.2472 mL
	5 mM	0.7540 mL	3.7699 mL	7.5398 mL	18.8494 mL
	10 mM	0.3770 mL	1.8849 mL	3.7699 mL	9.4247 mL
	15 mM	0.2513 mL	1.2566 mL	2.5133 mL	6.2831 mL
	20 mM	0.1885 mL	0.9425 mL	1.8849 mL	4.7124 mL
	25 mM	0.1508 mL	0.7540 mL	1.5080 mL	3.7699 mL
	30 mM	0.1257 mL	0.6283 mL	1.2566 mL	3.1416 mL
	40 mM	0.0942 mL	0.4712 mL	0.9425 mL	2.3562 mL
	50 mM	0.0754 mL	0.3770 mL	0.7540 mL	1.8849 mL
	60 mM	0.0628 mL	0.3142 mL	0.6283 mL	1.5708 mL
	80 mM	0.0471 mL	0.2356 mL	0.4712 mL	1.1781 mL
	100 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9425 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.