L-Phenylalanine-¹⁵N,d₈ (Synonyms: (S)-2-Amino-3-phenylpropionic acid-¹⁵N,d₈)

Cat. No.: HY-N0215S14 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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L-Phenylalanine-¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

For research use only. We do not sell to patients.

L-Phenylalanine-<sup>15</sup>N,d<sub>8</sub> Chemical Structure

L-Phenylalanine-¹⁵N,d₈ Chemical Structure

Size	Price	Stock
1 mg	USD 50	Ask For Quote & Lead Time

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Other Forms of L-Phenylalanine-¹⁵N,d₈:

L-Phenylalanine In-stock

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NMDA Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

174.23

Formula

C₉H₃D₈¹⁵NO₂

Unlabeled CAS

63-91-2

Appearance

Solid

Color

White to off-white

SMILES

[15NH2][C@](C([2H])([2H])C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 16.67 mg/mL (95.68 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7395 mL	28.6977 mL	57.3954 mL
5 mM	1.1479 mL	5.7395 mL	11.4791 mL
10 mM	0.5740 mL	2.8698 mL	5.7395 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (253 KB) HNMR (283 KB) LCMS (104 KB) OR (215 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.7395 mL	28.6977 mL	57.3954 mL	143.4885 mL
	5 mM	1.1479 mL	5.7395 mL	11.4791 mL	28.6977 mL
	10 mM	0.5740 mL	2.8698 mL	5.7395 mL	14.3488 mL
	15 mM	0.3826 mL	1.9132 mL	3.8264 mL	9.5659 mL
	20 mM	0.2870 mL	1.4349 mL	2.8698 mL	7.1744 mL
	25 mM	0.2296 mL	1.1479 mL	2.2958 mL	5.7395 mL
	30 mM	0.1913 mL	0.9566 mL	1.9132 mL	4.7829 mL
	40 mM	0.1435 mL	0.7174 mL	1.4349 mL	3.5872 mL
	50 mM	0.1148 mL	0.5740 mL	1.1479 mL	2.8698 mL
	60 mM	0.0957 mL	0.4783 mL	0.9566 mL	2.3915 mL
	80 mM	0.0717 mL	0.3587 mL	0.7174 mL	1.7936 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Phenylalanine-¹⁵N,d₈ Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Phenylalanine-¹⁵N,d₈(S)-2-Amino-3-phenylpropionic acid-¹⁵N,d₈Isotope-Labeled CompoundsCalcium ChanneliGluREndogenous MetaboliteCa2+ channelsCa channelsIonotropic glutamate receptorsInhibitorinhibitorinhibit

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L-Phenylalanine-15N,d8 (Synonyms: (S)-2-Amino-3-phenylpropionic acid-15N,d8)

Other Forms of L-Phenylalanine-15N,d8:

L-Phenylalanine-15N,d8 Related Antibodies