2. Others Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite
  4. L-Phenylalanine-15N,d8

L-Phenylalanine-15N,d8  (Synonyms: (S)-2-Amino-3-phenylpropionic acid-15N,d8)

Cat. No.: HY-N0215S14 Purity: 99.90%
COA Handling Instructions

Molarity Calculator

L-Phenylalanine-15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

For research use only. We do not sell to patients.

L-Phenylalanine-<sup>15</sup>N,d<sub>8</sub> Chemical Structure

L-Phenylalanine-15N,d8 Chemical Structure

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Other Forms of L-Phenylalanine-15N,d8:

L-Phenylalanine-15N,d8 Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

L-Phenylalanine-15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

IC50 & Target

NMDA Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Phenylalanine-15N,d8 Related Antibodies
Molecular Weight

174.23

Formula

C9H3D815NO2
Unlabeled CAS

63-91-2
Appearance

Solid

Color

White to off-white

SMILES

[15NH2][C@](C([2H])([2H])C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])([2H])C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (95.68 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7395 mL 28.6977 mL 57.3954 mL
5 mM 1.1479 mL 5.7395 mL 11.4791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.7395 mL 28.6977 mL 57.3954 mL 143.4885 mL
5 mM 1.1479 mL 5.7395 mL 11.4791 mL 28.6977 mL
10 mM 0.5740 mL 2.8698 mL 5.7395 mL 14.3488 mL
15 mM 0.3826 mL 1.9132 mL 3.8264 mL 9.5659 mL
20 mM 0.2870 mL 1.4349 mL 2.8698 mL 7.1744 mL
25 mM 0.2296 mL 1.1479 mL 2.2958 mL 5.7395 mL
30 mM 0.1913 mL 0.9566 mL 1.9132 mL 4.7829 mL
40 mM 0.1435 mL 0.7174 mL 1.4349 mL 3.5872 mL
50 mM 0.1148 mL 0.5740 mL 1.1479 mL 2.8698 mL
60 mM 0.0957 mL 0.4783 mL 0.9566 mL 2.3915 mL
80 mM 0.0717 mL 0.3587 mL 0.7174 mL 1.7936 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Phenylalanine-15N,d8 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Phenylalanine-15N,d8(S)-2-Amino-3-phenylpropionic acid-15N,d8Isotope-Labeled CompoundsCalcium ChanneliGluREndogenous MetaboliteCa2+ channelsCa channelsIonotropic glutamate receptorsInhibitorinhibitorinhibit

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