2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. Calcium Channel iGluR Endogenous Metabolite
  4. L-Phenylalanine

L-Phenylalanine  (Synonyms: Phenylalanine)

Cat. No.: HY-N0215 Purity: 99.96%
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L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

For research use only. We do not sell to patients.

L-Phenylalanine Chemical Structure

L-Phenylalanine Chemical Structure

CAS No. : 63-91-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 2 publication(s) in Google Scholar

Other Forms of L-Phenylalanine:

L-Phenylalanine Related Antibodies

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Description

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

IC50 & Target

Microbial Metabolite

 

NMDA Receptor

 

Human Endogenous Metabolite

 

In Vitro

DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine[1]. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Phenylalanine Related Antibodies
In Vivo

The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

165.19

Formula

C9H11NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CC=CC=C1)C(O)=O
Structure Classification
Initial Source

Escherichia coli
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (40.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0536 mL 30.2678 mL 60.5356 mL
5 mM 1.2107 mL 6.0536 mL 12.1071 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 9.09 mg/mL (55.03 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

SDS (393 KB)

COA (247 KB) HNMR (123 KB) RP-HPLC (191 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.0536 mL 30.2678 mL 60.5356 mL 151.3390 mL
5 mM 1.2107 mL 6.0536 mL 12.1071 mL 30.2678 mL
10 mM 0.6054 mL 3.0268 mL 6.0536 mL 15.1339 mL
15 mM 0.4036 mL 2.0179 mL 4.0357 mL 10.0893 mL
20 mM 0.3027 mL 1.5134 mL 3.0268 mL 7.5670 mL
25 mM 0.2421 mL 1.2107 mL 2.4214 mL 6.0536 mL
30 mM 0.2018 mL 1.0089 mL 2.0179 mL 5.0446 mL
40 mM 0.1513 mL 0.7567 mL 1.5134 mL 3.7835 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Phenylalanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Phenylalanine63-91-2PhenylalanineCalcium ChanneliGluREndogenous MetaboliteCa2+ channelsCa channelsIonotropic glutamate receptorsEssentialvoltage-dependentα2δNMDAnon-NMDApostsynapticDAHPchorismatemutaseprephenateInhibitorinhibitorinhibit

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