L-Phenylalanine-d₅

Name: L-Phenylalanine-d 5
Brand: MedChemExpress
SKU: HY-N0215S12
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0215S12 Purity: 99.15%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Phenylalanine-d₅ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

For research use only. We do not sell to patients.

L-Phenylalanine-d<sub>5</sub> Chemical Structure

L-Phenylalanine-d₅ Chemical Structure

CAS No. : 56253-90-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Phenylalanine-d₅:

L-Phenylalanine In-stock

1 Publications Citing Use of MCE L-Phenylalanine-d₅

•ACS Cent Sci. 2024 Aug 28;10(9):1789-1802. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NMDA Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

170.22

Formula

C₉H₆D₅NO₂

CAS No.

56253-90-8

Unlabeled CAS

63-91-2

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 12.5 mg/mL (73.43 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8748 mL	29.3738 mL	58.7475 mL
5 mM	1.1750 mL	5.8748 mL	11.7495 mL
10 mM	0.5875 mL	2.9374 mL	5.8748 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.15%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) HNMR (258 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.8748 mL	29.3738 mL	58.7475 mL	146.8688 mL
	5 mM	1.1750 mL	5.8748 mL	11.7495 mL	29.3738 mL
	10 mM	0.5875 mL	2.9374 mL	5.8748 mL	14.6869 mL
	15 mM	0.3917 mL	1.9583 mL	3.9165 mL	9.7913 mL
	20 mM	0.2937 mL	1.4687 mL	2.9374 mL	7.3434 mL
	25 mM	0.2350 mL	1.1750 mL	2.3499 mL	5.8748 mL
	30 mM	0.1958 mL	0.9791 mL	1.9583 mL	4.8956 mL
	40 mM	0.1469 mL	0.7343 mL	1.4687 mL	3.6717 mL
	50 mM	0.1175 mL	0.5875 mL	1.1750 mL	2.9374 mL
	60 mM	0.0979 mL	0.4896 mL	0.9791 mL	2.4478 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.