2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  3. EGFR Autophagy Ferroptosis
  4. Lapatinib-d4

Lapatinib-d4  (Synonyms: GW572016-d4; GW2016-d4)

Cat. No.: HY-50898S Purity: 99.02%
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Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].

For research use only. We do not sell to patients.

Lapatinib-d<sub>4</sub> Chemical Structure

Lapatinib-d4 Chemical Structure

CAS No. : 1184263-99-7

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1 mg USD 450 In-stock
5 mg USD 1450 In-stock
10 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Lapatinib-d4:

Lapatinib-d4 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lapatinib-d4 Related Antibodies
Molecular Weight

585.08

Formula

C29H22D4ClFN4O4S
CAS No.
Unlabeled CAS

231277-92-2
Appearance

Solid

Color

Light yellow to yellow

SMILES

CS(C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C2=CC(C(NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=NC=N5)=C5C=C2)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (213.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 125 mg/mL (213.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7092 mL 8.5458 mL 17.0917 mL
5 mM 0.3418 mL 1.7092 mL 3.4183 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.7092 mL 8.5458 mL 17.0917 mL 42.7292 mL
5 mM 0.3418 mL 1.7092 mL 3.4183 mL 8.5458 mL
10 mM 0.1709 mL 0.8546 mL 1.7092 mL 4.2729 mL
15 mM 0.1139 mL 0.5697 mL 1.1394 mL 2.8486 mL
20 mM 0.0855 mL 0.4273 mL 0.8546 mL 2.1365 mL
25 mM 0.0684 mL 0.3418 mL 0.6837 mL 1.7092 mL
30 mM 0.0570 mL 0.2849 mL 0.5697 mL 1.4243 mL
40 mM 0.0427 mL 0.2136 mL 0.4273 mL 1.0682 mL
50 mM 0.0342 mL 0.1709 mL 0.3418 mL 0.8546 mL
60 mM 0.0285 mL 0.1424 mL 0.2849 mL 0.7122 mL
80 mM 0.0214 mL 0.1068 mL 0.2136 mL 0.5341 mL
100 mM 0.0171 mL 0.0855 mL 0.1709 mL 0.4273 mL
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Lapatinib-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lapatinib-d41184263-99-7GW572016-d4GW2016-d4EGFRAutophagyFerroptosisEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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