2. Anti-infection
  3. Bacterial
  4. LasR-IN-4

LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production.

For research use only. We do not sell to patients.

LasR-IN-4 Chemical Structure

LasR-IN-4 Chemical Structure

CAS No. : 183488-96-2

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Based on 1 publication(s) in Google Scholar

LasR-IN-4 Related Antibodies

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Description

LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production[1].

IC50 & Target

MIC: 56.25 μg/mL (P. aeruginosa)[1]
In Vitro

LasR-IN-4 (compound 3d) has inhibitory activity against P. aeruginosa with MIC of 56.25 μg/mL, and inhibits biofilm formation, pyocyanin production, and rhamnolipids production of 71.70%, 68.70% and 54.00%, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LasR-IN-4 Related Antibodies
Molecular Weight

292.38

Formula

C18H20N4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN1CCN(C2=CC=C(C3=NC4=CC=CC=C4N3)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (171.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4202 mL 17.1010 mL 34.2021 mL
5 mM 0.6840 mL 3.4202 mL 6.8404 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4202 mL 17.1010 mL 34.2021 mL 85.5052 mL
5 mM 0.6840 mL 3.4202 mL 6.8404 mL 17.1010 mL
10 mM 0.3420 mL 1.7101 mL 3.4202 mL 8.5505 mL
15 mM 0.2280 mL 1.1401 mL 2.2801 mL 5.7003 mL
20 mM 0.1710 mL 0.8551 mL 1.7101 mL 4.2753 mL
25 mM 0.1368 mL 0.6840 mL 1.3681 mL 3.4202 mL
30 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
40 mM 0.0855 mL 0.4275 mL 0.8551 mL 2.1376 mL
50 mM 0.0684 mL 0.3420 mL 0.6840 mL 1.7101 mL
60 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
80 mM 0.0428 mL 0.2138 mL 0.4275 mL 1.0688 mL
100 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8551 mL
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LasR-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LasR-IN-4183488-96-2BacterialantibacterialbiofilmpyocyaninrhamnolipidsPseudomonas aeruginosaInhibitorinhibitorinhibit

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