2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. LASSBio-873

LASSBio-873 is an orally active muscarinic cholinergic receptor (mAChR) agonist that crosses the blood-brain barrier. LASSBio-873 has potent analgesic effects on acute and inflammatory pain. The analgesic effect of LASSBio-873 can be inhibited by intrathecal injection of the M2 receptor antagonist methoctramine.

For research use only. We do not sell to patients.

LASSBio-873 Chemical Structure

LASSBio-873 Chemical Structure

CAS No. : 873694-54-3

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5 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

LASSBio-873 Related Antibodies

Top Publications Citing Use of Products

View All mAChR Isoform Specific Products:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

LASSBio-873 is an orally active muscarinic cholinergic receptor (mAChR) agonist that crosses the blood-brain barrier. LASSBio-873 has potent analgesic effects on acute and inflammatory pain. The analgesic effect of LASSBio-873 can be inhibited by intrathecal injection of the M2 receptor antagonist methoctramine[1].

Molecular Weight

399.36

Formula

C21H13N5O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1N(C2=CC=C([N+]([O-])=O)C=C2)C(C3=C1C=NC4=C3C(C)=NN4C5=CC=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (5.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5040 mL 12.5200 mL 25.0401 mL
5 mM 0.5008 mL 2.5040 mL 5.0080 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation

Purity: 99.82%

COA (250 KB) HNMR (418 KB) RP-HPLC (266 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5040 mL 12.5200 mL 25.0401 mL 62.6002 mL
5 mM 0.5008 mL 2.5040 mL 5.0080 mL 12.5200 mL
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LASSBio-873 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LASSBio-873873694-54-3LASSBio873LASSBio 873mAChRMuscarinic acetylcholine receptorblood-brain barrierorally activeanalgesicinflammatorypainM2 receptormethoctramineInhibitorinhibitorinhibit

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