Lenalidomide-C10-OH

Cat. No.: HY-139563: FAQs
Data Sheet Handling Instructions

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Lenalidomide-C10-OH (6a) is an intermediate in the synthesis of INY-03-041.

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Lenalidomide-C10-OH Chemical Structure

CAS No. : 2503018-12-8

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Description

Lenalidomide-C10-OH (6a) is an intermediate in the synthesis of INY-03-041^[1].

Molecular Weight

400.51

Formula

C₂₃H₃₂N₂O₄

CAS No.

2503018-12-8

SMILES

O=C(C(N(CC1=C2C=CC=C1CCCCCCCCCCO)C2=O)CC3)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 110 mg/mL (274.65 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4968 mL	12.4841 mL	24.9682 mL
5 mM	0.4994 mL	2.4968 mL	4.9936 mL
10 mM	0.2497 mL	1.2484 mL	2.4968 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. You I, et, al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4968 mL	12.4841 mL	24.9682 mL	62.4204 mL
	5 mM	0.4994 mL	2.4968 mL	4.9936 mL	12.4841 mL
	10 mM	0.2497 mL	1.2484 mL	2.4968 mL	6.2420 mL
	15 mM	0.1665 mL	0.8323 mL	1.6645 mL	4.1614 mL
	20 mM	0.1248 mL	0.6242 mL	1.2484 mL	3.1210 mL
	25 mM	0.0999 mL	0.4994 mL	0.9987 mL	2.4968 mL
	30 mM	0.0832 mL	0.4161 mL	0.8323 mL	2.0807 mL
	40 mM	0.0624 mL	0.3121 mL	0.6242 mL	1.5605 mL
	50 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2484 mL
	60 mM	0.0416 mL	0.2081 mL	0.4161 mL	1.0403 mL
	80 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7803 mL
	100 mM	0.0250 mL	0.1248 mL	0.2497 mL	0.6242 mL