Lenalidomide-C5-NH2 TFA 

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader^[1][2].

443.42

C₂₀H₂₄F₃N₃O₅

2550398-71-3

Solid

Light yellow to yellow

O=C(C(N(CC1=C2C=CC=C1CCCCCN)C2=O)CC3)NC3=O.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018;61(2):462-481.  [Content Brief]

  [2]. Li Y, Yang J, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019;62(2):448-466.  [Content Brief]