Lenalidomide-C5-NH2 hydrochloride

Cat. No.: HY-122725B Purity: 98.44%: FAQs
Data Sheet SDS COA Handling Instructions

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Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.

For research use only. We do not sell to patients.

Lenalidomide-C5-NH2 hydrochloride Chemical Structure

CAS No. : 2595367-27-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 440	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 440	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Lenalidomide-C5-NH2 hydrochloride:

Lenalidomide-C5-NH2 In-stock
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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Cereblon

Molecular Weight

365.85

Formula

C₁₈H₂₄ClN₃O₃

CAS No.

2595367-27-2

Appearance

Solid

Color

White to yellow

SMILES

O=C1C(C=CC=C2CCCCCN)=C2CN1C3C(NC(CC3)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (136.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7334 mL	13.6668 mL	27.3336 mL
5 mM	0.5467 mL	2.7334 mL	5.4667 mL
10 mM	0.2733 mL	1.3667 mL	2.7334 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.44%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (255 KB) LCMS (244 KB)

Handling Instructions (2659 KB)

References

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [Content Brief]

[2]. Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7334 mL	13.6668 mL	27.3336 mL	68.3340 mL
	5 mM	0.5467 mL	2.7334 mL	5.4667 mL	13.6668 mL
	10 mM	0.2733 mL	1.3667 mL	2.7334 mL	6.8334 mL
	15 mM	0.1822 mL	0.9111 mL	1.8222 mL	4.5556 mL
	20 mM	0.1367 mL	0.6833 mL	1.3667 mL	3.4167 mL
	25 mM	0.1093 mL	0.5467 mL	1.0933 mL	2.7334 mL
	30 mM	0.0911 mL	0.4556 mL	0.9111 mL	2.2778 mL
	40 mM	0.0683 mL	0.3417 mL	0.6833 mL	1.7084 mL
	50 mM	0.0547 mL	0.2733 mL	0.5467 mL	1.3667 mL
	60 mM	0.0456 mL	0.2278 mL	0.4556 mL	1.1389 mL
	80 mM	0.0342 mL	0.1708 mL	0.3417 mL	0.8542 mL
	100 mM	0.0273 mL	0.1367 mL	0.2733 mL	0.6833 mL