2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling NF-κB Apoptosis
  3. JAK Keap1-Nrf2 Apoptosis
  4. Lentinan

Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering[1][4].

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Lentinan Chemical Structure

Lentinan Chemical Structure

CAS No. : 37339-90-5

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Based on 3 publication(s) in Google Scholar

Lentinan Related Antibodies

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Description

Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering[1][4].
In Vitro

Lentinan (100 μg/mL, 6 h) inhibits oxidative stress and alleviates LPS induced inflammation and apoptosis in bovine mammary epithelial cells by activating the Nrf2 signaling pathway[1].
Lentinan (0-200 μM, 24 h) reduces proliferation, migration, invasion, and cell stemness of lung adenocarcinoma cell lines H1299 and H460, and promotes cell apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lentinan Related Antibodies

Real Time qPCR[1].

Cell Line: lipopolysaccharide (LPS)-induced injury of bovine mammary epithelial cells (BMECs)
Concentration: 100 μg/mL
Incubation Time: 6 h
Result: Increased the gene expression of CAT and HO-1.

Cell Viability Assay[4].

Cell Line: Human LUAD cell lines H1299 and H460
Concentration: 0-200 μM
Incubation Time: 24 h
Result: Reduced cell viability and proliferation ability of H1299 and H460
In Vivo

Lentinan (5, 10, 20 mg/kg; once a day; 5 days; p.o.) exerts anti influenza effect in ICR mice by regulating the TLR4/MyD88 signaling pathway to inhibit inflammatory response[2].
Lentinan (40, 100, 250 mg/kg; once a day; 5 days; i.p.) improves sepsis in burned mice by reducing Erk-FoxO1 signaling pathway and inhibiting regulatory T cell function[3].
Lentinan (100 μM, 200 μL; once a day; s.c.) upregulates miR-216a-5p by inhibiting the JAK2/STAT3 signaling pathway to slow down the occurrence and development of mouse lung adenocarcinoma[4].
Lentinan (200 mg/kg; once a day; 14 days; p.o.) can improve antibiotic induced intestinal inflammation and dysbiosis in mice[5].
Lentinan (10 mg/kg; once a day; 12 weeks; p.o.) alleviates diabetes cardiomyopathy in mice by inhibiting CAV1/SDHA regulated mitochondrial dysfunction[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Virus-infected ICR mice[2].
Dosage: 5, 10, 20 mg/kg
Administration: Oral gavage (p.o.); once a day; 5 days
Result: Had a high degree of protection in mice against infection with influenza A virus, delayed the emergence of clinical manifestations, improved the survival rate of mice, significantly prolonged the middle survival days, attenuated the weight loss, and reduced the lung coefficient of mice.
Animal Model: Male BALB/c mice model of burn plus P. aeruginosa infection[3].
Dosage: 40, 100, 250 mg/kg
Administration: Intraperitoneal injection (i.p.); once a day; 5 days
Result: Reduced lipopolysaccharide induced IL-10 production and weakened LPS stimulated Erk-FoxO1 activation in Tregs isolated from burned mice.
Animal Model: Male BALB/c nude mice with H1299 cells[4].
Dosage: 100 μM, 200 μL
Administration: Subcutaneous injection (s.c.); once a day
Result: Reduced tumor volume, weight, and Ki-67 expression levels.
Animal Model: Antibiotic-driven gut microbial dysbiosis mice[5].
Dosage: 200 mg/kg
Administration: Oral gavage (p.o.); once a day; 14 days
Result: Reversed the dysbiosis and increased beneficial microbiota, including S24-7, Lactobacillus, Oscillospira, Ruminococcus and Allobaculum.
Animal Model: Male db/db mice[6].
Dosage: 10 mg/kg
Administration: Oral gavage (p.o.); once a day; 12 weeks
Result: Restored diastolic function and alleviated myocardial remodeling in diabetic cardiomyopathy (DCM).
Clinical Trial
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

[Lentinan]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

0.1 M NaOH : 33.33 mg/mL (ultrasonic and adjust pH to 9 with NaOH)

Acetone : < 1 mg/mL (insoluble)

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Purity & Documentation

COA (241 KB)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lentinan37339-90-5JAKKeap1-Nrf2ApoptosisJanus kinaseanti-inflammatoryantioxidantdiabetic cardiomyopathylung adenocarcinomaInhibitorinhibitorinhibit

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