1. Anti-infection
  2. Bacterial
  3. Leoidin

Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 µM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC50= 42 µM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides.

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Leoidin Chemical Structure

Leoidin Chemical Structure

CAS No. : 105350-54-7

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Description

Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 µM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC50= 42 µM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides[1][2].

Molecular Weight

413.21

Formula

C18H14Cl2O7

CAS No.
SMILES

O=C(C1=C(O)C(C)=C(C(OC2=C(Cl)C(O)=C(Cl)C(C)=C23)=C1C)OC3=O)OC

Structure Classification
Initial Source

L. gangaleoides

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Room temperature in continental US; may vary elsewhere.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Leoidin
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HY-N8497
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