2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Leteprinim potassium

Leteprinim potassium  (Synonyms: AIT-082)

Cat. No.: HY-120251A Purity: ≥99.0%
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Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species.

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Leteprinim potassium Chemical Structure

Leteprinim potassium Chemical Structure

CAS No. : 192564-13-9

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Based on 1 publication(s) in Google Scholar

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Leteprinim potassium Related Antibodies

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Description

Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4].

In Vitro

Leteprinim (5-50 ng/mL, 24 and 48 h) potassium enhances neurotransmitter release, increases secretion of synaptophysin in PC12 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leteprinim potassium Related Antibodies
In Vivo

Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4]
Dosage: 60 mg/kg
Administration: IP; single dosage
Result: The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.
In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.
Clinical Trial
Molecular Weight

365.39

Formula

C15H12KN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)NC(CCN2C=NC3=C2N=CNC3=O)=O)O[K]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

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Handling Instructions (2659 KB)
References
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Leteprinim potassium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leteprinim192564-13-9AIT-082AIT082AIT 082Reactive Oxygen SpeciesNeurotrophicBDNFNGFhippocampalneuronsheme-oxygenaseneuroprotectivehypoxic-ischemic brain injuryPC12Inhibitorinhibitorinhibit

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