Lidocaine-d₁₀

Name: Lidocaine-d 10
Brand: MedChemExpress
SKU: HY-B0185S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0185S1 Purity: 98.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

For research use only. We do not sell to patients.

Lidocaine-d<sub>10</sub> Chemical Structure

Lidocaine-d₁₀ Chemical Structure

CAS No. : 851528-09-1

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Lidocaine-d₁₀:

Lidocaine In-stock

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•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

View All MEK Isoform Specific Products:

View All Isoforms

MEK1 MEK2 MEK5 MEK

View All ERK Isoform Specific Products:

View All Isoforms

ERK ERK1 ERK2 ERK5 ERK8

View All NF-κB Isoform Specific Products:

View All Isoforms

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

244.40

Formula

C₁₄H₁₂D₁₀N₂O

CAS No.

851528-09-1

Unlabeled CAS

73-78-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

[2H]C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])[2H])CC(NC1=C(C=CC=C1C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (409.17 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0917 mL	20.4583 mL	40.9165 mL
5 mM	0.8183 mL	4.0917 mL	8.1833 mL
10 mM	0.4092 mL	2.0458 mL	4.0917 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.89%

Select Batch:

Data Sheet (276 KB) SDS (392 KB)

COA (254 KB) HNMR (226 KB) RP-HPLC (575 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11. [Content Brief]

[3]. Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19(1):233. [Content Brief]

[4]. Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113(1):31-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0917 mL	20.4583 mL	40.9165 mL	102.2913 mL
	5 mM	0.8183 mL	4.0917 mL	8.1833 mL	20.4583 mL
	10 mM	0.4092 mL	2.0458 mL	4.0917 mL	10.2291 mL
	15 mM	0.2728 mL	1.3639 mL	2.7278 mL	6.8194 mL
	20 mM	0.2046 mL	1.0229 mL	2.0458 mL	5.1146 mL
	25 mM	0.1637 mL	0.8183 mL	1.6367 mL	4.0917 mL
	30 mM	0.1364 mL	0.6819 mL	1.3639 mL	3.4097 mL
	40 mM	0.1023 mL	0.5115 mL	1.0229 mL	2.5573 mL
	50 mM	0.0818 mL	0.4092 mL	0.8183 mL	2.0458 mL
	60 mM	0.0682 mL	0.3410 mL	0.6819 mL	1.7049 mL
	80 mM	0.0511 mL	0.2557 mL	0.5115 mL	1.2786 mL
	100 mM	0.0409 mL	0.2046 mL	0.4092 mL	1.0229 mL