2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel Calcium Channel
  4. Lidoflazine

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia.

For research use only. We do not sell to patients.

Lidoflazine Chemical Structure

Lidoflazine Chemical Structure

CAS No. : 3416-26-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 946 In-stock
Solution
10 mM * 1 mL in DMSO USD 946 In-stock
Solid
1 mg USD 215 In-stock
5 mg USD 537 In-stock
10 mg USD 860 In-stock
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Based on 1 publication(s) in Google Scholar

Lidoflazine Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
17.39 μM
Compound: LIDOFLAZINE
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
10.21203/rs.3.rs-23951/v1
Caco-2 CC50
31.91 μM
Compound: LIDOFLAZINE
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
10.21203/rs.3.rs-23951/v1
K562 IC50
4954 nM
Compound: Lidoflazine
Inhibition of ENT1 in human K562 cells by flow cytometric assay
Inhibition of ENT1 in human K562 cells by flow cytometric assay
[PMID: 17636949]
In Vitro

Lidoflazine inhibits potently HERG current (IHERG) recorded from HEK 293 cells stably expressing wild-type HERG (IC50 of ~16 nM).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lidoflazine Related Antibodies
Molecular Weight

491.62

Formula

C30H35F2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(C)C=CC=C1C)CN2CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14 mg/mL (28.48 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0341 mL 10.1705 mL 20.3409 mL
5 mM 0.4068 mL 2.0341 mL 4.0682 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.10%

SDS (251 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0341 mL 10.1705 mL 20.3409 mL 50.8523 mL
5 mM 0.4068 mL 2.0341 mL 4.0682 mL 10.1705 mL
10 mM 0.2034 mL 1.0170 mL 2.0341 mL 5.0852 mL
15 mM 0.1356 mL 0.6780 mL 1.3561 mL 3.3902 mL
20 mM 0.1017 mL 0.5085 mL 1.0170 mL 2.5426 mL
25 mM 0.0814 mL 0.4068 mL 0.8136 mL 2.0341 mL
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Lidoflazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lidoflazine3416-26-0Potassium ChannelCalcium ChannelKcsACa2+ channelsCa channelsInhibitorinhibitorinhibit

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