2. Protein Tyrosine Kinase/RTK
  3. VEGFR PDGFR
  4. Linifanib

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells.

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Linifanib Chemical Structure

Linifanib Chemical Structure

CAS No. : 796967-16-3

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Linifanib Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All PDGFR Isoform Specific Products:

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PDGFR PDGFRβ PDGFRα

  • Biological Activity

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  • References

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Description

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells[1].

IC50 & Target

IC50: 4 nM (KDR), 4 nM (FLT1), 66 nM (PDGFRβ), 3 nM (CSF-1R), 4 nM (FLT3), 14 nM (Kit)[1]
In Vitro

Linifanib (GMP) (1 μM) induces generation of hCiPS cells from human embryonic fibroblasts (HEFs)[1].
Linifanib (GMP) (1 μM) induces generation of hCiPS cells from hADSCs or hASFs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Linifanib Related Antibodies
Clinical Trial
Molecular Weight

375.40

Formula

C21H18FN5O
CAS No.
SMILES

O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Linifanib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linifanib (GMP)796967-16-3ABT-869 (GMP) AL-39324 (GMP)VEGFRPDGFRVascular endothelial growth factor receptorPlatelet-derived growth factor receptorGMPcell therapydifferentiatesomatic celltransdifferentiatehCiPSreprogrammingInhibitorinhibitorinhibit

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