Liproxstatin-1 hydrochloride

Name: Liproxstatin-1 hydrochloride
Brand: MedChemExpress
SKU: HY-12726A
Rating: 5.0 (168 reviews)

Cat. No.: HY-12726A Purity: 99.31%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM).

For research use only. We do not sell to patients.

Liproxstatin-1 hydrochloride Chemical Structure

CAS No. : 2250025-95-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 168 publication(s) in Google Scholar

Other Forms of Liproxstatin-1 hydrochloride:

159 Publications Citing Use of MCE Liproxstatin-1 hydrochloride

RT-PCR

Proliferation Assay

Cell Viability Assay

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec 5:79:103460. [Abstract]; 143B and SJSA-1 cells were treated with SFN with or without Lip-1 (1 μM) for 48 h, and cell viability was evaluated.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Nov 5:78:103419. [Abstract]; Cell viability of the control NCI–H358, Calu-1, NCI–H23, MIA PaCa-2 and the corresponding resistant cell lines after 24 h of treatment with the indicated compounds. 2 μM liproxstatin-1 (Lip-1), 10 μM sorafenib or 10 μM lapatinib was used to treat NCI–H358, NCI–H23 and MIA PaCa-2 cells, while Calu-1 cells were treated with 2 μM liproxstatin-1 (Lip-1), 3 μM sorafenib or 10 μM lapatinib (n = 3).

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 24:480:135952. [Abstract]; Liproxstatin-1 (100 nM; 50 h) alleviates the decrease in O-GlcNAcylation levels and ferroptosis-related proteins in AML12 cells caused by DON (48 h) exposure.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Jul 2;14(10):4090-4106. [Abstract]; Liproxstatin 1 (Lip-1) (48 h) 在Hela 细胞中可以很大程度上逆转由 p62 敲低增强的铁死亡诱导剂的细胞毒性。

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May 23:73:103207. [Abstract]; Cell survival of 5FU-R cells treated with a gradient concentration of PUFAs and 10 μM ferrostatin-1, or 10 μM liproxstatin-1 for 24 h.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: MedComm. 2024 Apr 4;5(4):e520. [Abstract]; Antiferroptosis treatment repressed the development of AS in vivo. Normal group: normal diet; HFD group: HFD for 3 months; HFD + ferrostatin‐1 group: HFD accompanied by ferrostatin‐1 treatment (1 mg/kg, twice a day, i.p.); HFD + liproxstatin‐1 group: HFD accompanied by liproxstatin‐1 treatment (10 mg/kg, twice a day, i.p.). IHC of 4‐HEN (ferroptosis marker) in aortic sinus.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov 16:e2303812. [Abstract]; Cell viability of HEC‐1A cells transfected with sh‐PRMT3 and treated with erastin in the absence or presence of liproxstatin‐1 (400 nm), ZVAD‐FMK (10 µm), 3‐methyladenine (1 mm) or necrosulfonamide (10 µm) for 48 h.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Jan, 304, 122430.; Liproxstatin-1 (1 μM). The concentration-dependent cytotoxicity of LysoCOS7, LysoRaw and LysoNeu in the presence of various inhibitors.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245. [Abstract]; The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM)^[1].

In Vitro

Liproxstatin-1 shows antiferroptotic activity with an IC₅₀ of approximately 38 nM in mouse embryonic fibroblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4^-/- kidney and in an ischaemia/reperfusion-induced tissue injury model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.31

Formula

C₁₉H₂₂Cl₂N₄

CAS No.

2250025-95-5

Appearance

Solid

Color

Light yellow to brown

SMILES

ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 5.83 mg/mL (15.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6503 mL	13.2517 mL	26.5034 mL
5 mM	0.5301 mL	2.6503 mL	5.3007 mL
10 mM	0.2650 mL	1.3252 mL	2.6503 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) HNMR (260 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91. [Content Brief]

[2]. Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6503 mL	13.2517 mL	26.5034 mL	66.2585 mL
	5 mM	0.5301 mL	2.6503 mL	5.3007 mL	13.2517 mL
	10 mM	0.2650 mL	1.3252 mL	2.6503 mL	6.6259 mL
	15 mM	0.1767 mL	0.8834 mL	1.7669 mL	4.4172 mL