Liproxstatin-1 hydrochloride

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Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM).

For research use only. We do not sell to patients.

Liproxstatin-1 hydrochloride Chemical Structure

CAS No. : 2250025-95-5

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Other In-stock Forms of Liproxstatin-1 hydrochloride:

Liproxstatin-1

Other Forms of Liproxstatin-1 hydrochloride:

128 Publications Citing Use of MCE Liproxstatin-1 hydrochloride

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: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245. [Abstract]; The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.

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Biological Activity
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Description	Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM)^[1].
In Vitro	Liproxstatin-1 shows antiferroptotic activity with an IC₅₀ of approximately 38 nM in mouse embryonic fibroblasts^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Liproxstatin-1 hydrochloride Related Antibodies
In Vivo	Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4^-/- kidney and in an ischaemia/reperfusion-induced tissue injury model^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	377.31
Formula	C₁₉H₂₂Cl₂N₄
CAS No.	2250025-95-5
SMILES	ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1.[H]Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91. [Content Brief] [2]. Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243 [Content Brief]