2. Apoptosis
  3. Ferroptosis
  4. Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM).

For research use only. We do not sell to patients.

Liproxstatin-1 hydrochloride Chemical Structure

Liproxstatin-1 hydrochloride Chemical Structure

CAS No. : 2250025-95-5

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Liproxstatin-1 hydrochloride Related Antibodies

Top Publications Citing Use of Products

159 Publications Citing Use of MCE Liproxstatin-1 hydrochloride

RT-PCR

    Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245.  [Abstract]

    The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.

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    Description

    Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1].

    In Vitro

    Liproxstatin-1 shows antiferroptotic activity with an IC50 of approximately 38 nM in mouse embryonic fibroblasts[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Liproxstatin-1 hydrochloride Related Antibodies
    In Vivo

    Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4-/- kidney and in an ischaemia/reperfusion-induced tissue injury model[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    377.31

    Formula

    C19H22Cl2N4
    CAS No.
    SMILES

    ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Liproxstatin-1 hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Liproxstatin-12250025-95-5Liproxstatin1Liproxstatin 1FerroptosisInhibitorinhibitorinhibit

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    Product Name:
    Liproxstatin-1 hydrochloride
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    HY-12726A
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