2. Others Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)
  4. Lisinopril-d5

Lisinopril-d5 is the deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

For research use only. We do not sell to patients.

Lisinopril-d<sub>5</sub> Chemical Structure

Lisinopril-d5 Chemical Structure

CAS No. : 1356905-39-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Lisinopril-d5:

Lisinopril-d5 Related Antibodies

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Description

Lisinopril-d5 is the deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lisinopril-d5 Related Antibodies
Molecular Weight

410.52

Formula

C21H26D5N3O5
CAS No.
Unlabeled CAS

76547-98-3
Appearance

Solid

SMILES

[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CC[C@@H](C(O)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (121.80 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4359 mL 12.1797 mL 24.3594 mL
5 mM 0.4872 mL 2.4359 mL 4.8719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4359 mL 12.1797 mL 24.3593 mL 60.8984 mL
5 mM 0.4872 mL 2.4359 mL 4.8719 mL 12.1797 mL
10 mM 0.2436 mL 1.2180 mL 2.4359 mL 6.0898 mL
15 mM 0.1624 mL 0.8120 mL 1.6240 mL 4.0599 mL
20 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0449 mL
25 mM 0.0974 mL 0.4872 mL 0.9744 mL 2.4359 mL
30 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0299 mL
40 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL
50 mM 0.0487 mL 0.2436 mL 0.4872 mL 1.2180 mL
60 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0150 mL
80 mM 0.0304 mL 0.1522 mL 0.3045 mL 0.7612 mL
100 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.6090 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lisinopril-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lisinopril-d51356905-39-9MK-521-d5Isotope-Labeled CompoundsAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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