Lisinopril (Synonyms: MK-521)

Name: Lisinopril
Brand: MedChemExpress
SKU: HY-18206
Rating: 5.0 (6 reviews)

Cat. No.: HY-18206 Purity: 99.93%: FAQs
Data Sheet SDS COA Handling Instructions

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Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

For research use only. We do not sell to patients.

Lisinopril Chemical Structure

CAS No. : 76547-98-3

Size	Price	Stock	Quantity
250 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Lisinopril:

Lisinopril dihydrate In-stock
Lisinopril-d₅ Get quote

4 Publications Citing Use of MCE Lisinopril

Cell Viability Assay

: Lisinopril purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336. [Abstract]; HK-2 cells are treated with 0, 5, 10, 20 and 40 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay. HK-2 cells are treated with 40 μM silibinin or/and 10 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay.

: Lisinopril purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336. [Abstract]; After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.

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Description

Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

IC₅₀ & Target

ACE.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	307 μM Compound: Lisinopril	Cytotoxicity against human A549 cells assessed as cell survival after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell survival after 24 hrs by MTT assay	[PMID: 23777825]
HEK293	IC₅₀	443 μM Compound: Lisinopril	Cytotoxicity against HEK293 cells assessed as cell survival after 24 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as cell survival after 24 hrs by MTT assay	[PMID: 23777825]

In Vitro

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

405.49

Formula

C₂₁H₃₁N₃O₅

CAS No.

76547-98-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H]1N(C([C@H](CCCCN)N[C@H](C(O)=O)CCC2=CC=CC=C2)=O)CCC1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (123.31 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4662 mL	12.3308 mL	24.6615 mL
5 mM	0.4932 mL	2.4662 mL	4.9323 mL
10 mM	0.2466 mL	1.2331 mL	2.4662 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (277 KB) SDS (557 KB)

COA (254 KB) HNMR (258 KB) RP-HPLC (237 KB)

Handling Instructions (2659 KB)

References

[1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54. [Content Brief]

[2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.4662 mL	12.3308 mL	24.6615 mL	61.6538 mL
	5 mM	0.4932 mL	2.4662 mL	4.9323 mL	12.3308 mL
	10 mM	0.2466 mL	1.2331 mL	2.4662 mL	6.1654 mL
	15 mM	0.1644 mL	0.8221 mL	1.6441 mL	4.1103 mL
	20 mM	0.1233 mL	0.6165 mL	1.2331 mL	3.0827 mL
	25 mM	0.0986 mL	0.4932 mL	0.9865 mL	2.4662 mL
	30 mM	0.0822 mL	0.4110 mL	0.8221 mL	2.0551 mL
	40 mM	0.0617 mL	0.3083 mL	0.6165 mL	1.5413 mL
	50 mM	0.0493 mL	0.2466 mL	0.4932 mL	1.2331 mL
	60 mM	0.0411 mL	0.2055 mL	0.4110 mL	1.0276 mL
	80 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.7707 mL
	100 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.6165 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Lisinopril Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lisinopril76547-98-3MK-521MK521MK 521Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Lisinopril (Synonyms: MK-521)

Customer Review

Other Forms of Lisinopril:

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4 Publications Citing Use of MCE Lisinopril

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Complete Stock Solution Preparation Table

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