2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Lisinopril

Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

For research use only. We do not sell to patients.

Lisinopril Chemical Structure

Lisinopril Chemical Structure

CAS No. : 76547-98-3

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Lisinopril:

Lisinopril Related Antibodies

Top Publications Citing Use of Products

    Lisinopril purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336.  [Abstract]

    HK-2 cells are treated with 0, 5, 10, 20 and 40 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay. HK-2 cells are treated with 40 μM silibinin or/and 10 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay.

    Lisinopril purchased from MedChemExpress. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336.  [Abstract]

    After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.

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    • Purity & Documentation

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    • Customer Review

    Description

    Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

    IC50 & Target

    ACE.
    In Vitro

    Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Lisinopril Related Antibodies
    Clinical Trial
    Molecular Weight

    405.49

    Formula

    C21H31N3O5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)[C@H]1N(C([C@H](CCCCN)N[C@H](C(O)=O)CCC2=CC=CC=C2)=O)CCC1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (123.31 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4662 mL 12.3308 mL 24.6615 mL
    5 mM 0.4932 mL 2.4662 mL 4.9323 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.93%

    COA (254 KB) HNMR (258 KB) RP-HPLC (237 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.4662 mL 12.3308 mL 24.6615 mL 61.6538 mL
    5 mM 0.4932 mL 2.4662 mL 4.9323 mL 12.3308 mL
    10 mM 0.2466 mL 1.2331 mL 2.4662 mL 6.1654 mL
    15 mM 0.1644 mL 0.8221 mL 1.6441 mL 4.1103 mL
    20 mM 0.1233 mL 0.6165 mL 1.2331 mL 3.0827 mL
    25 mM 0.0986 mL 0.4932 mL 0.9865 mL 2.4662 mL
    30 mM 0.0822 mL 0.4110 mL 0.8221 mL 2.0551 mL
    40 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.5413 mL
    50 mM 0.0493 mL 0.2466 mL 0.4932 mL 1.2331 mL
    60 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0276 mL
    80 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7707 mL
    100 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6165 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Lisinopril Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lisinopril76547-98-3MK-521MK521MK 521Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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