2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Livmoniplimab

Livmoniplimab  (Synonyms: ABBV-151; ARGX-115)

Cat. No.: HY-P99708 Purity: 99.25%
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Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors.

For research use only. We do not sell to patients.

CAS No. : 2412004-88-5

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Based on 1 publication(s) in Google Scholar

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Description

Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors[1][2].
Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
In Vivo

Livmoniplimab (250 μg; three times a week; 3 weeks; i.p.) exhibits anti-tumor activity in colon cancer mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old female B-hGARP mice subcutaneously inoculated with MC38 mouse colon cancer cells[2].
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.); three times a week; 3 weeks
Result: Resulted in 34.3% tumor growth inhibition.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Livmoniplimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation
References
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Livmoniplimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Livmoniplimab2412004-88-5ABBV-151 ARGX-115ABBV151ABBV 151ARGX115ARGX 115ARGX-115TGF-beta/SmadTransforming growth factor betaantibodyGARP/TGF-β1solid tumorInhibitorinhibitorinhibit

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