Lomtegovimab (Synonyms: BI 767551; DZIF-10c)

Cat. No.: HY-P99710: FAQs
Data Sheet

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Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19.

For research use only. We do not sell to patients.

CAS No. : 2550869-33-3

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Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species

Human

In Vitro

Lomtegovimab targets the RBD of SARS-CoV-2 S with a K_D value of 1.09 nM^[2].
Lomtegovimab shows neutralizing activity with IC₅₀s of 0.001, 0.001, 0.010 µg/mL for SARS-CoV-2 S D614G, SARS-CoV-2 S B.1.1.7, SARS-CoV-2 BavPat1 (B.1), respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lomtegovimab (40 mg/kg; i.p. or i.n.; once; three days before infection) protects hACE2-transduced mice from infection with SARS-CoV-2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice (Ad_ACE2-mCherry)^[2]
Dosage:	40 mg/kg
Administration:	I.p. or I.n.; once; three days before infection
Result:	Led to a complete neutralization of infectious SARS-CoV-2 and slightly reduced amounts of viral RNA in the lungs of treated animals.

Clinical Trial

CAS No.

2550869-33-3

SMILES

[Lomtegovimab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

Human IgG1 kappa

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Halwe S, et al. Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Viruses. 2021 Jul 29;13(8):1498. [Content Brief]

Lomtegovimab Related Classifications

Infection

Inhibitory Antibodies

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lomtegovimab2550869-33-3BI 767551 DZIF-10cBI767551BI-767551SARS-CoVSARS coronavirusSARS-COV-2antiviralhACE2neutralizing antibodyInhibitorinhibitorinhibit

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