2. Others GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Isotope-Labeled Compounds Histamine Receptor
  4. Loratadine-d5

Loratadine-d5  (Synonyms: Loratidine-d5; SCH 29851-d5)

Cat. No.: HY-17043S1 Purity: 99.96%
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Loratadine-d5 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

For research use only. We do not sell to patients.

Loratadine-d<sub>5</sub> Chemical Structure

Loratadine-d5 Chemical Structure

CAS No. : 1398065-63-8

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1 mg USD 120 In-stock
5 mg USD 280 In-stock
10 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Loratadine-d5:

Loratadine-d5 Related Antibodies

Top Publications Citing Use of Products

View All Histamine Receptor Isoform Specific Products:

View All Isoforms
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • Biological Activity

  • Purity & Documentation

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Description

Loratadine-d5 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

IC50 & Target

H1 Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Loratadine-d5 Related Antibodies
Molecular Weight

387.91

Formula

C22H18D5ClN2O2
CAS No.
Unlabeled CAS

79794-75-5
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(/C(C2=NC=CC=C2CC3)=C4CCN(CC/4)C(OC([2H])([2H])C([2H])([2H])[2H])=O)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5779 mL 12.8896 mL 25.7792 mL
5 mM 0.5156 mL 2.5779 mL 5.1558 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5779 mL 12.8896 mL 25.7792 mL 64.4479 mL
5 mM 0.5156 mL 2.5779 mL 5.1558 mL 12.8896 mL
10 mM 0.2578 mL 1.2890 mL 2.5779 mL 6.4448 mL
15 mM 0.1719 mL 0.8593 mL 1.7186 mL 4.2965 mL
20 mM 0.1289 mL 0.6445 mL 1.2890 mL 3.2224 mL
25 mM 0.1031 mL 0.5156 mL 1.0312 mL 2.5779 mL
30 mM 0.0859 mL 0.4297 mL 0.8593 mL 2.1483 mL
40 mM 0.0644 mL 0.3222 mL 0.6445 mL 1.6112 mL
50 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2890 mL
60 mM 0.0430 mL 0.2148 mL 0.4297 mL 1.0741 mL
80 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.8056 mL
100 mM 0.0258 mL 0.1289 mL 0.2578 mL 0.6445 mL
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Loratadine-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Loratadine-d51398065-63-8Loratidine-d5SCH 29851-d5Isotope-Labeled CompoundsHistamine ReceptorInhibitorinhibitorinhibit

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