2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. Lovastatin hydroxy acid sodium

Lovastatin hydroxy acid sodium  (Synonyms: Mevinolinic acid sodium)

Cat. No.: HY-123672 Purity: 99.50%
COA Handling Instructions

Molarity Calculator

Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.

For research use only. We do not sell to patients.

Lovastatin hydroxy acid sodium Chemical Structure

Lovastatin hydroxy acid sodium Chemical Structure

CAS No. : 75225-50-2

Size Price Stock Quantity
1 mg USD 60 In-stock
5 mg USD 240 In-stock
10 mg USD 380 In-stock
25 mg USD 760 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Lovastatin hydroxy acid sodium:

Lovastatin hydroxy acid sodium Related Antibodies

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Description

Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

IC50 & Target

Ki: 0.6 nM (HMG-CoA reductase)[1]
In Vitro

Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lovastatin hydroxy acid sodium Related Antibodies
Molecular Weight

444.54

Formula

C24H37NaO6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC([C@H](CC)C)=O)C)C)O)O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (28.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 12.5 mg/mL (28.12 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2495 mL 11.2476 mL 22.4952 mL
5 mM 0.4499 mL 2.2495 mL 4.4990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

COA (250 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.2495 mL 11.2476 mL 22.4952 mL 56.2379 mL
5 mM 0.4499 mL 2.2495 mL 4.4990 mL 11.2476 mL
10 mM 0.2250 mL 1.1248 mL 2.2495 mL 5.6238 mL
15 mM 0.1500 mL 0.7498 mL 1.4997 mL 3.7492 mL
20 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8119 mL
25 mM 0.0900 mL 0.4499 mL 0.8998 mL 2.2495 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lovastatin hydroxy acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lovastatin hydroxy acid75225-50-2Mevinolinic acidHMG-CoA Reductase (HMGCR)CholesterolLoweringAgentHMG-CoAreductaseInhibitorinhibitorinhibit

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