2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. LP 12 hydrochloride hydrate

LP 12 hydrochloride hydrate 

Cat. No.: HY-103105A Purity: ≥99.0%
SDS COA Handling Instructions

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LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively).

For research use only. We do not sell to patients.

LP 12 hydrochloride hydrate Chemical Structure

LP 12 hydrochloride hydrate Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of LP 12 hydrochloride hydrate:

LP 12 hydrochloride hydrate Related Antibodies

Top Publications Citing Use of Products

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1][2].

In Vitro

LP 12 hydrochloride hydrate (0.13 nM; spermatozoa) increases the percentage of hyperactivated spermatozoa. LP 12 hydrochloride hydrate do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LP 12 hydrochloride hydrate Related Antibodies
Formula

C32H39N3O.HCl.xH2O
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl.[x].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References
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LP 12 hydrochloride hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LP 12 hydrochloride5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorpronociceptive effectshyperactivated spermatozoastraight-line velocitycurvilinear velocityInhibitorinhibitorinhibit

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