2. Epigenetics
  3. Histone Demethylase
  4. LSD1/2-IN-3

LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation.

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LSD1/2-IN-3 Chemical Structure

LSD1/2-IN-3 Chemical Structure

CAS No. : 2821068-07-7

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LSD1/2-IN-3 Related Antibodies

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Description

LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation[1].

IC50 & Target

KDM1/LSD1

 

In Vitro

LSD1/2-IN-3 (compound 8c) inhibits proliferation of the T-cell acute lymphoblastic leukemia (T-ALL) with IC50s of 25 μM (CCRF-CEM) and 27 μM (Jurkat), respectively, without inhibiting the human normal fibroblast cell line WI-38[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1/2-IN-3 Related Antibodies
Molecular Weight

248.07

Formula

C9H8BrF2N
CAS No.
SMILES

N[C@@H]1C[C@@H]1C2=CC(F)=C(Br)C(F)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1/2-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1/2-IN-32821068-07-7Histone Demethylasedemethylates mono- and dimethylated lysineH3K4H3K9T-cell acute lymphoblastic leukemiaT-ALL2-phenylcyclopropylaminePCPAInhibitorinhibitorinhibit

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