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  4. LU-005i

LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM).

For research use only. We do not sell to patients.

LU-005i Chemical Structure

LU-005i Chemical Structure

CAS No. : 1620107-33-6

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1 mg USD 220 In-stock
5 mg USD 580 In-stock
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LU-005i Related Antibodies

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Description

LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].

IC50 & Target

β5i subunit of immunoproteasomes (IC50 = 6.6 nM), β5c subunit of immunoproteasomes (IC50 = 287 nM)[1]
Molecular Weight

586.72

Formula

C31H46N4O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1C[C@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)C(N[C@@H](CC3CCCCC3)C([C@]4(CO4)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (170.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7044 mL 8.5220 mL 17.0439 mL
5 mM 0.3409 mL 1.7044 mL 3.4088 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7044 mL 8.5220 mL 17.0439 mL 42.6098 mL
5 mM 0.3409 mL 1.7044 mL 3.4088 mL 8.5220 mL
10 mM 0.1704 mL 0.8522 mL 1.7044 mL 4.2610 mL
15 mM 0.1136 mL 0.5681 mL 1.1363 mL 2.8407 mL
20 mM 0.0852 mL 0.4261 mL 0.8522 mL 2.1305 mL
25 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7044 mL
30 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4203 mL
40 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
50 mM 0.0341 mL 0.1704 mL 0.3409 mL 0.8522 mL
60 mM 0.0284 mL 0.1420 mL 0.2841 mL 0.7102 mL
80 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5326 mL
100 mM 0.0170 mL 0.0852 mL 0.1704 mL 0.4261 mL
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LU-005i Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LU-005i1620107-33-6Othersβ5i subunit of immunoproteasomesβ5c subunit of immunoproteasomesInhibitorinhibitorinhibit

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