LU-005i

Cat. No.: HY-148732 Purity: 97.43%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC₅₀ = 6.6 nM), selective over β5c subunit (IC₅₀ = 287 nM).

For research use only. We do not sell to patients.

LU-005i Chemical Structure

CAS No. : 1620107-33-6

Size	Price	Stock	Quantity
1 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC₅₀ = 6.6 nM), selective over β5c subunit (IC₅₀ = 287 nM)^[1].

IC₅₀ & Target

β5i subunit of immunoproteasomes (IC₅₀ = 6.6 nM), β5c subunit of immunoproteasomes (IC₅₀ = 287 nM)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Raji	IC₅₀	> 10 μM Compound: 8, LU-005i	Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry	[PMID: 25006746]
Raji	IC₅₀	0.3 μM Compound: 8, LU-005i	Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry	[PMID: 25006746]
Raji	IC₅₀	0.41 μM Compound: 8, LU-005i	Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry	[PMID: 25006746]
Raji	IC₅₀	2.5 μM Compound: 8, LU-005i	Inhibition of 20s proteasome subunit beta-2c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry Inhibition of 20s proteasome subunit beta-2c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry	[PMID: 25006746]
Raji	IC₅₀	287 nM Compound: 8, LU-005i	Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 by fluorescent densitometry Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 by fluorescent densitometry	[PMID: 25006746]
Raji	IC₅₀	6.6 nM Compound: 8, LU-005i	Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	> 5 μM Compound: 8, LU-005i	Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	0.044 μM Compound: 8, LU-005i	Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	0.37 μM Compound: 8, LU-005i	Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	0.9 μM Compound: 8, LU-005i	Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	4.2 μM Compound: 8, LU-005i	Inhibition of 20s proteasome subunit beta-5c in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry Inhibition of 20s proteasome subunit beta-5c in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	4.9 μM Compound: 8, LU-005i	Inhibition of 20s proteasome subunit beta-2c in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry Inhibition of 20s proteasome subunit beta-2c in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry	[PMID: 25006746]

Molecular Weight

586.72

Formula

C₃₁H₄₆N₄O₇

CAS No.

1620107-33-6

Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1C[C@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)C(N[C@@H](CC3CCCCC3)C([C@]4(CO4)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (170.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7044 mL	8.5220 mL	17.0439 mL
5 mM	0.3409 mL	1.7044 mL	3.4088 mL
10 mM	0.1704 mL	0.8522 mL	1.7044 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.43%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) RP-HPLC (247 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Rezvan Moallemian, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.Biochem Pharmacol. 2020 Jul:177:113964. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7044 mL	8.5220 mL	17.0439 mL	42.6098 mL
	5 mM	0.3409 mL	1.7044 mL	3.4088 mL	8.5220 mL
	10 mM	0.1704 mL	0.8522 mL	1.7044 mL	4.2610 mL
	15 mM	0.1136 mL	0.5681 mL	1.1363 mL	2.8407 mL
	20 mM	0.0852 mL	0.4261 mL	0.8522 mL	2.1305 mL
	25 mM	0.0682 mL	0.3409 mL	0.6818 mL	1.7044 mL
	30 mM	0.0568 mL	0.2841 mL	0.5681 mL	1.4203 mL
	40 mM	0.0426 mL	0.2130 mL	0.4261 mL	1.0652 mL
	50 mM	0.0341 mL	0.1704 mL	0.3409 mL	0.8522 mL
	60 mM	0.0284 mL	0.1420 mL	0.2841 mL	0.7102 mL
	80 mM	0.0213 mL	0.1065 mL	0.2130 mL	0.5326 mL
	100 mM	0.0170 mL	0.0852 mL	0.1704 mL	0.4261 mL

LU-005i Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LU-005i1620107-33-6Othersβ5i subunit of immunoproteasomesβ5c subunit of immunoproteasomesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks