Lugdunin

Cat. No.: HY-P4200 Purity: 95.44%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lugdunin Chemical Structure

CAS No. : 1989698-37-4

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1 mg		Check price and availability

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

783.04

Formula

C₄₀H₆₂N₈O₆S

CAS No.

1989698-37-4

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (63.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2771 mL	6.3854 mL	12.7707 mL
5 mM	0.2554 mL	1.2771 mL	2.5541 mL
10 mM	0.1277 mL	0.6385 mL	1.2771 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.44%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (262 KB) RP-HPLC (112 KB) MS (205 KB)

Handling Instructions (2659 KB)

References

[1]. Bitschar K, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019 Jun 21;10(1):2730. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2771 mL	6.3854 mL	12.7707 mL	31.9269 mL
	5 mM	0.2554 mL	1.2771 mL	2.5541 mL	6.3854 mL
	10 mM	0.1277 mL	0.6385 mL	1.2771 mL	3.1927 mL
	15 mM	0.0851 mL	0.4257 mL	0.8514 mL	2.1285 mL
	20 mM	0.0639 mL	0.3193 mL	0.6385 mL	1.5963 mL
	25 mM	0.0511 mL	0.2554 mL	0.5108 mL	1.2771 mL
	30 mM	0.0426 mL	0.2128 mL	0.4257 mL	1.0642 mL
	40 mM	0.0319 mL	0.1596 mL	0.3193 mL	0.7982 mL
	50 mM	0.0255 mL	0.1277 mL	0.2554 mL	0.6385 mL
	60 mM	0.0213 mL	0.1064 mL	0.2128 mL	0.5321 mL

Lugdunin Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lugdunin1989698-37-4BacterialAntibioticS. aureusantibacterialantibiotic peptideInhibitorinhibitorinhibit

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