Lumateperone-CH_{C,d3 tosylate}  (Synonyms: ITI-007-CH_{C,d3 tosylate)}

Lumateperone-¹³C,d₃ (ITI-007-¹³C,d₃) tosylate is ¹³C and deuterium labeled Lumateperone (tosylate). Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia^[1][2][3][4].

569.71

C₃₀¹³CH₃₃D₃FN₃O₄S

1187020-80-9

O=C(CCCN1C[C@@]([H])(C2=CC=CC3=C2N4CCN3[13C]([2H])([2H])[2H])[C@]4([H])CC1)C5=CC=C(F)C=C5.CC6=CC=C(C=C6)S(O)(=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Lumateperone

  [3]. Jinyuan Zhang, et al. Identification of Trovafloxacin, Ozanimod, and Ozenoxacin as Potent c-Myc G-quadruplex Stabilizers to Suppress c-Myc Transcription and Myeloma Growth. Mol Inform. 2022 Mar 30:e2200011.  [Content Brief]

  [4]. J Titulaer, et al. Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D1 receptor dependent mechanism. Eur Neuropsychopharmacol. 2022 Jul 22;62:22-35.  [Content Brief]