Lurasidone-d₈-1 hydrochloride  (Synonyms: SM-13496-d₈-1 hydrochloride)

Lurasidone-d₈-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM^[1].

537.19

C₂₈H₂₉D₈ClN₄O₂S

367514-88-3

[H][C@]12C[C@@]([H])(CC2)[C@@]3([H])[C@]1([H])C(N(C3=O)C[C@@H]4CCCC[C@H]4CN5C([2H])(C([2H])(N(C([2H])(C5([2H])[2H])[2H])C6=NSC7=C6C=CC=C7)[2H])[2H])=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.

  [3]. Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.  [Content Brief]