2. Others Immunology/Inflammation
  3. Isotope-Labeled Compounds Thrombopoietin Receptor
  4. Lusutrombopag-d13

Lusutrombopag-d13  (Synonyms: S-888711-d13)

Cat. No.: HY-19883S Purity: 98.64%
COA Handling Instructions

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Lusutrombopag-d13 is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

For research use only. We do not sell to patients.

Lusutrombopag-d<sub>13</sub> Chemical Structure

Lusutrombopag-d13 Chemical Structure

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1 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Lusutrombopag-d13:

Lusutrombopag-d13 Related Antibodies

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Description

Lusutrombopag-d13 is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lusutrombopag-d13 Related Antibodies
Molecular Weight

604.63

Formula

C29H19D13Cl2N2O5S
Unlabeled CAS

1110766-97-6
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C(C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C)=C3OC)=CS2)=O)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33 mg/mL (54.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6539 mL 8.2695 mL 16.5390 mL
5 mM 0.3308 mL 1.6539 mL 3.3078 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6539 mL 8.2695 mL 16.5390 mL 41.3476 mL
5 mM 0.3308 mL 1.6539 mL 3.3078 mL 8.2695 mL
10 mM 0.1654 mL 0.8270 mL 1.6539 mL 4.1348 mL
15 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7565 mL
20 mM 0.0827 mL 0.4135 mL 0.8270 mL 2.0674 mL
25 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6539 mL
30 mM 0.0551 mL 0.2757 mL 0.5513 mL 1.3783 mL
40 mM 0.0413 mL 0.2067 mL 0.4135 mL 1.0337 mL
50 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8270 mL
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Lusutrombopag-d13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lusutrombopag-d13S-888711-d13Isotope-Labeled CompoundsThrombopoietin ReceptorInhibitorinhibitorinhibit

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