2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics
  3. HIF/HIF Prolyl-Hydroxylase AMPK
  4. LW1564

LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model.

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LW1564 Chemical Structure

LW1564 Chemical Structure

CAS No. : 2668337-39-9

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LW1564 Related Antibodies

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Description

LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model[1].

Molecular Weight

731.84

Formula

C42H48F3N3O5
CAS No.
SMILES

O=C(COC1=CC=C(C23CC4CC(C3)CC(C4)(C2)C(N5CC6=CC(OC)=C(C=C6CC5)OC)=O)C=C1)N7CCN(CC7)CC8=CC=C(C(F)(F)F)C=C8
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LW1564 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LW15642668337-39-9LW 1564LW-1564HIF/HIF Prolyl-HydroxylaseAMPKHypoxia-inducible factorsHIFsHIF-PHAMP-activated protein kinaseHepG2mouseHCT116HCT15LoVoSW480SW620WiDrHT1080NCI-N87NUGC3SNU484HT17Huh7SHJ1SKHep1AsPC1MIA-PaCa2CCD-34LuWI-38Inhibitorinhibitorinhibit

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