2. GPCR/G Protein
  3. LPL Receptor
  4. LX2931

LX2931 is an inhibitor of Sphingosine 1-Phosphate Lyase (S1PL). LX2931 works by increasing levels of S1P inside and outside the cell. The decrease in S1PL activity leads to a significant increase in S1P content in tissues, especially in lymphoid tissues which may lead to a restricted exodus of lymphocytes from secondary immune tissues, resulting in lymphocytopenic and immunosuppressive effects in the peripheral circulation. LX2931 can be used in research for the treatment of autoimmune diseases, especially rheumatoid arthritis.

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LX2931 Chemical Structure

LX2931 Chemical Structure

CAS No. : 948840-25-3

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Based on 1 publication(s) in Google Scholar

LX2931 Related Antibodies

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Description

LX2931 is an inhibitor of Sphingosine 1-Phosphate Lyase (S1PL). LX2931 works by increasing levels of S1P inside and outside the cell. The decrease in S1PL activity leads to a significant increase in S1P content in tissues, especially in lymphoid tissues which may lead to a restricted exodus of lymphocytes from secondary immune tissues, resulting in lymphocytopenic and immunosuppressive effects in the peripheral circulation. LX2931 can be used in research for the treatment of autoimmune diseases, especially rheumatoid arthritis[1].

Molecular Weight

245.23

Formula

C9H15N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O)[C@@H](O)[C@@H](C1=CN=C(/C(C)=N/O)N1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (407.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0778 mL 20.3890 mL 40.7780 mL
5 mM 0.8156 mL 4.0778 mL 8.1556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0778 mL 20.3890 mL 40.7780 mL 101.9451 mL
5 mM 0.8156 mL 4.0778 mL 8.1556 mL 20.3890 mL
10 mM 0.4078 mL 2.0389 mL 4.0778 mL 10.1945 mL
15 mM 0.2719 mL 1.3593 mL 2.7185 mL 6.7963 mL
20 mM 0.2039 mL 1.0195 mL 2.0389 mL 5.0973 mL
25 mM 0.1631 mL 0.8156 mL 1.6311 mL 4.0778 mL
30 mM 0.1359 mL 0.6796 mL 1.3593 mL 3.3982 mL
40 mM 0.1019 mL 0.5097 mL 1.0195 mL 2.5486 mL
50 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0389 mL
60 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6991 mL
80 mM 0.0510 mL 0.2549 mL 0.5097 mL 1.2743 mL
100 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0195 mL
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LX2931 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LX2931948840-25-3LX 2931LX-2931LPL ReceptorLysophospholipid ReceptorAutoimmune diseaselymphocytesinhibitorescape restrictionS1PLInhibitorinhibit

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