2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. LIM Kinase (LIMK) ROCK PKA
  4. LX7101 monohydrochloride

LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.

For research use only. We do not sell to patients.

LX7101 monohydrochloride Chemical Structure

LX7101 monohydrochloride Chemical Structure

CAS No. : 2319882-48-7

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LX7101 monohydrochloride Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE LX7101 monohydrochloride

WB
Proliferation Assay

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Mar 16.  [Abstract]

    Both LX7101 (5 μM) and TH-257 (5 μM) inhibits the colony-forming ability of melanoma cells (A375-MA2, MeWo, and SK-MEL-147 cells) in soft-agar.

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Mar 16.  [Abstract]

    Both LX7101 (5 μM; 24 h) and TH-257 (5 μM; 24 h) reduces the phosphorylation of G3BP1 in A375-MA2 and SK-MEL-147 cells.

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Aug 2;8(1):11585.  [Abstract]

    Western blot analysis of GFAP protein levels in LX7101 and DMSO-treated iNPC-KO lines. GAPDH is used as a loading control.

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    LIMK1 LIMK2

    View All ROCK Isoform Specific Products:

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    ROCK ROCK1 ROCK2

    View All PKA Isoform Specific Products:

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    PKA PKAR

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    • References

    • Customer Review

    Description

    LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research[1][2].

    IC50 & Target[1]

    LIMK1

    24 nM (IC50)

    LIMK2

    1.6 nM (IC50)

    ROCK2

    10 nM (IC50)

    PKA

    <1 nM (IC50)

    In Vivo

    LX7101 (200 μg/40 μL eye drop) monohydrochloride displays a significant intraocular pressure (IOP) reduction at time points ranging from 1 h to 6 h post administration in ocular normotensive New Zealand White (NZW) rabbits[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    487.98

    Formula

    C23H30ClN7O3
    CAS No.
    SMILES

    NCC1(C(NC2=CC(OC(N(C)C)=O)=CC=C2)=O)CCN(C3=C4C(NC=C4C)=NC=N3)CC1.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    LX7101 monohydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LX7101 monohydrochloride2319882-48-7LIM Kinase (LIMK)ROCKPKALIMKsRho-associated protein kinaseRho-associated kinaseRho-kinaseROKProtein kinase Aocular hypertensionglaucomaInhibitorinhibitorinhibit

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