LY 165163 (Synonyms: p-NH2-PE-TFMPP)

Cat. No.: HY-124501 Purity: 99.24%: FAQs
Data Sheet SDS COA Handling Instructions

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LY 165163 is a potent 5-HT presynaptic receptor agonist. LY 165163 significantly decreases 5-HTP accumulation and increases DOPA accumulation in the cortex and striatum.

For research use only. We do not sell to patients.

LY 165163 Chemical Structure

CAS No. : 1814-64-8

Size	Price	Stock	Quantity
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 830	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1330	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

LY 165163 is a potent 5-HT presynaptic receptor agonist. LY 165163 significantly decreases 5-HTP accumulation and increases DOPA accumulation in the cortex and striatum^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Astrocyte	EC₅₀	21.82 μM Compound: PAPP	Antiproliferative activity against mouse astrocyte cells by MTT assay Antiproliferative activity against mouse astrocyte cells by MTT assay	[PMID: 17417631]
Medulloblastoma cell	EC₅₀	0.169 μM Compound: PAPP	Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay	[PMID: 17417631]

Molecular Weight

349.39

Formula

C₁₉H₂₂F₃N₃

CAS No.

1814-64-8

Appearance

Solid

Color

White to off-white

SMILES

NC1=CC=C(C=C1)CCN2CCN(CC2)C3=CC=CC(C(F)(F)F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 50 mg/mL (143.11 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8621 mL	14.3107 mL	28.6213 mL
5 mM	0.5724 mL	2.8621 mL	5.7243 mL
10 mM	0.2862 mL	1.4311 mL	2.8621 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.24%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (244 KB) HNMR (116 KB) RP-HPLC (423 KB) LCMS (339 KB)

Handling Instructions (2659 KB)

References

[1]. Hutson P H, et al. Neurochemical and behavioural evidence for an agonist action of 1-[2-(4-aminophenyl) ethyl]-4-(3-trifluoromethylphenyl) piperazine (LY 165163) at central 5-HT receptors[J]. European journal of pharmacology, 1987, 138(2): 215-223.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	2.8621 mL	14.3107 mL	28.6213 mL	71.5533 mL
	5 mM	0.5724 mL	2.8621 mL	5.7243 mL	14.3107 mL
	10 mM	0.2862 mL	1.4311 mL	2.8621 mL	7.1553 mL
	15 mM	0.1908 mL	0.9540 mL	1.9081 mL	4.7702 mL
	20 mM	0.1431 mL	0.7155 mL	1.4311 mL	3.5777 mL
	25 mM	0.1145 mL	0.5724 mL	1.1449 mL	2.8621 mL
	30 mM	0.0954 mL	0.4770 mL	0.9540 mL	2.3851 mL
	40 mM	0.0716 mL	0.3578 mL	0.7155 mL	1.7888 mL
	50 mM	0.0572 mL	0.2862 mL	0.5724 mL	1.4311 mL
	60 mM	0.0477 mL	0.2385 mL	0.4770 mL	1.1926 mL
	80 mM	0.0358 mL	0.1789 mL	0.3578 mL	0.8944 mL
	100 mM	0.0286 mL	0.1431 mL	0.2862 mL	0.7155 mL

LY 165163 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 1651631814-64-8p-NH2-PE-TFMPPLY165163LY-1651635-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorpresynapticInhibitorinhibitorinhibit

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LY 165163 (Synonyms: p-NH2-PE-TFMPP)

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LY 165163 Related Antibodies

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References

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Complete Stock Solution Preparation Table

LY 165163 Related Classifications

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