2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. LY3154885

LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile.

For research use only. We do not sell to patients.

LY3154885 Chemical Structure

LY3154885 Chemical Structure

CAS No. : 2379422-72-5

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LY3154885 Related Antibodies

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Description

LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
16.4 nM
Compound: 1
Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay
Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay
[PMID: 31938453]
Clinical Trial
Molecular Weight

444.35

Formula

C23H23Cl2N3O2
CAS No.
SMILES

CN1N=CC(C2=CC=CC3=C2C[C@H](CO)N(C(CC4=C(Cl)C=CC=C4Cl)=O)[C@H]3C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY3154885 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY31548852379422-72-5LY 3154885LY-3154885Dopamine Receptordopamine D1 receptor positive allosteric modulatordrug-drug interactionsInhibitorinhibitorinhibit

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