2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)  (Synonyms: LMN-NKA)

Cat. No.: HY-P3849 Purity: 99.83%
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[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues.

For research use only. We do not sell to patients.

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[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Chemical Structure

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Chemical Structure

CAS No. : 149270-28-0

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10 mg USD 110 In-stock
25 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Related Antibodies

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Description

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3].

IC50 & Target[1]

NK2

 

In Vivo

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (30-100 μg/kg, s.c.) increases peak bladder and colorectal pressures in minipigs[1].
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (0.3 μg/kg i.v. or 100 μg/kg i.n.) also increases bladder and colorectal pressures[1].
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (10-100 μg/kg, i.v., four times daily for six consecutive days) elicits micturition and defecation, emesis and hypotension in conscious dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized minipigs[1]
Dosage: 30-100 μg/kg
Administration: Subcutaneous injection (s.c.)
Result: Showed significant, non-linear, dose-dependent increase in peak bladder and colorectal pressures, and was blocked by GR 159897 (HY-107691)(1 mg/kg i.v., 15 min prior to LMN-NKA).
Animal Model: Conscious dogs[2]
Dosage: 10-100 μg/kg
Administration: Intravenous injection (i.v.), four times daily for six consecutive days.
Result: Elicited NK2 receptor-mediated micturition defecation and NK1 receptor-mediated emesis and hypotension.
Molecular Weight

804.97

Formula

C39H64N8O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

DKFVGL(N-Me)-Nle-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (31.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2423 mL 6.2114 mL 12.4228 mL
5 mM 0.2485 mL 1.2423 mL 2.4846 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2423 mL 6.2114 mL 12.4228 mL 31.0571 mL
5 mM 0.2485 mL 1.2423 mL 2.4846 mL 6.2114 mL
10 mM 0.1242 mL 0.6211 mL 1.2423 mL 3.1057 mL
15 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0705 mL
20 mM 0.0621 mL 0.3106 mL 0.6211 mL 1.5529 mL
25 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2423 mL
30 mM 0.0414 mL 0.2070 mL 0.4141 mL 1.0352 mL
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[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)149270-28-0LMN-NKANeurokinin ReceptorNK receptorTachykinin receptorProkineticmicturitiondefecationemesishypotensioncontractionsmooth muscleInhibitorinhibitorinhibit

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