2. Epigenetics
  3. Epigenetic Reader Domain
  4. M‑89

M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.

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M‑89 Chemical Structure

M‑89 Chemical Structure

CAS No. : 2363165-42-6

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1 mg USD 208 In-stock
5 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

M‑89 Related Antibodies

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Description

M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1].

IC50 & Target

Kd: 1.4 nM (menin)[1].
Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
10.2 μM
Compound: 42; M-89
Growth inhibition of human HL60 cells after 4 days by WST-8 assay
Growth inhibition of human HL60 cells after 4 days by WST-8 assay
[PMID: 31244110]
MOLM-13 IC50
0.054 μM
Compound: 42; M-89
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
[PMID: 31244110]
MV4-11 IC50
0.025 μM
Compound: 42; M-89
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
[PMID: 31244110]
Molecular Weight

657.87

Formula

C37H47N5O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC)O[C@@H]1[C@@H]([C@]2(C3CCN(CC4CN(C5=CC=C(S(=O)(C6=CC=NC=C6)=O)C=C5)C4)CC3)CN(C)CC7=C2C=CC=C7)CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 7.35 mg/mL (11.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5201 mL 7.6003 mL 15.2006 mL
5 mM 0.3040 mL 1.5201 mL 3.0401 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5201 mL 7.6003 mL 15.2006 mL 38.0014 mL
5 mM 0.3040 mL 1.5201 mL 3.0401 mL 7.6003 mL
10 mM 0.1520 mL 0.7600 mL 1.5201 mL 3.8001 mL
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M‑89 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M‑892363165-42-6Epigenetic Reader DomainInhibitorinhibitorinhibit

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