m-Carboxycinnamic acid bishydroxamide (Synonyms: CBHA)

Cat. No.: HY-W014004 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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m-Carboxycinnamic acid bishydroxamide is a potent HDAC inhibitor, exhibiting ID₅₀ values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively. m-Carboxycinnamic acid bishydroxamide also induces apoptosis and suppresses tumor growth.

For research use only. We do not sell to patients.

m-Carboxycinnamic acid bishydroxamide Chemical Structure

CAS No. : 174664-65-4

Size	Price	Stock	Quantity
5 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

m-Carboxycinnamic acid bishydroxamide is a potent HDAC inhibitor, exhibiting ID₅₀ values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively^[1]. m-Carboxycinnamic acid bishydroxamide also induces apoptosis and suppresses tumor growth^[2].

Molecular Weight

222.20

Formula

C₁₀H₁₀N₂O₄

CAS No.

174664-65-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(/C=C/C(NO)=O)=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (112.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5005 mL	22.5023 mL	45.0045 mL
5 mM	0.9001 mL	4.5005 mL	9.0009 mL
10 mM	0.4500 mL	2.2502 mL	4.5005 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)

References

[1]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7. [Content Brief]

[2]. Glick RD, et al. Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res. 1999 Sep 1;59(17):4392-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5005 mL	22.5023 mL	45.0045 mL	112.5113 mL
	5 mM	0.9001 mL	4.5005 mL	9.0009 mL	22.5023 mL
	10 mM	0.4500 mL	2.2502 mL	4.5005 mL	11.2511 mL
	15 mM	0.3000 mL	1.5002 mL	3.0003 mL	7.5008 mL
	20 mM	0.2250 mL	1.1251 mL	2.2502 mL	5.6256 mL
	25 mM	0.1800 mL	0.9001 mL	1.8002 mL	4.5005 mL
	30 mM	0.1500 mL	0.7501 mL	1.5002 mL	3.7504 mL
	40 mM	0.1125 mL	0.5626 mL	1.1251 mL	2.8128 mL
	50 mM	0.0900 mL	0.4500 mL	0.9001 mL	2.2502 mL
	60 mM	0.0750 mL	0.3750 mL	0.7501 mL	1.8752 mL
	80 mM	0.0563 mL	0.2813 mL	0.5626 mL	1.4064 mL
	100 mM	0.0450 mL	0.2250 mL	0.4500 mL	1.1251 mL

m-Carboxycinnamic acid bishydroxamide Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-Carboxycinnamic acid bishydroxamide174664-65-4CBHAHDACHistone deacetylasesInhibitorinhibitorinhibit

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m-Carboxycinnamic acid bishydroxamide (Synonyms: CBHA)

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m-Carboxycinnamic acid bishydroxamide Related Antibodies

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Complete Stock Solution Preparation Table

m-Carboxycinnamic acid bishydroxamide Related Classifications

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