2. PROTAC
  3. PROTAC Linkers
  4. m-PEG-NHS ester (MW 20000)

m-PEG-NHS ester (MW 20000)  (Synonyms: mPEG-SC (MW 20000); mPEG-Succinimidyl ester (MW 20000))

Cat. No.: HY-140700 Purity: ≥98.0%
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m-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG-NHS ester (MW 20000) Chemical Structure

m-PEG-NHS ester (MW 20000) Chemical Structure

CAS No. : 92451-01-9

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10 mg USD 140 In-stock
25 mg USD 220 In-stock
50 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

m-PEG-NHS ester (MW 20000) Related Antibodies

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View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

m-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG-NHS ester (MW 20000) Related Antibodies
Molecular Weight

20000(Average)

Formula

(C2H4O)nC7H9NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COCCOCC(ON1C(CCC1=O)=O)=O.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
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m-PEG-NHS ester (MW 20000) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG-NHS ester (MW 20000)92451-01-9mPEG-SC (MW 20000) mPEG-Succinimidyl ester (MW 20000)PROTAC LinkersInhibitorinhibitorinhibit

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m-PEG-NHS ester (MW 20000)
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