m-PEG11-Amine

Cat. No.: HY-W040222: FAQs
Data Sheet Handling Instructions

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m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG11-Amine Chemical Structure

CAS No. : 854601-60-8

Size	Price	Stock
100 mg	USD 59	Ask For Quote & Lead Time
250 mg	USD 101	Ask For Quote & Lead Time
500 mg	USD 172	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
Customer Review

Description

m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

Cleavable Linker

PEGs

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

515.64

Formula

C₂₃H₄₉NO₁₁

CAS No.

854601-60-8

Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Erwin R. Boghaert, et al. Anti-egfr antibody drug conjugates. WO2017214282A1.

m-PEG11-Amine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG11-Amine854601-60-8ADC LinkerPROTAC LinkersAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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