2. PROTAC
  3. PROTAC Linkers
  4. m-PEG11-OH

m-PEG11-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG11-OH Chemical Structure

m-PEG11-OH Chemical Structure

CAS No. : 2168540-65-4

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Based on 1 publication(s) in Google Scholar

m-PEG11-OH Related Antibodies

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Description

m-PEG11-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG11-OH Related Antibodies
Molecular Weight

516.62

Formula

C23H48O12
CAS No.
Appearance

Liquid (Density: 1.086 g/cm3)

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (193.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9357 mL 9.6783 mL 19.3566 mL
5 mM 0.3871 mL 1.9357 mL 3.8713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9357 mL 9.6783 mL 19.3566 mL 48.3915 mL
5 mM 0.3871 mL 1.9357 mL 3.8713 mL 9.6783 mL
10 mM 0.1936 mL 0.9678 mL 1.9357 mL 4.8391 mL
15 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2261 mL
20 mM 0.0968 mL 0.4839 mL 0.9678 mL 2.4196 mL
25 mM 0.0774 mL 0.3871 mL 0.7743 mL 1.9357 mL
30 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6130 mL
40 mM 0.0484 mL 0.2420 mL 0.4839 mL 1.2098 mL
50 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
60 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8065 mL
80 mM 0.0242 mL 0.1210 mL 0.2420 mL 0.6049 mL
100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.4839 mL
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m-PEG11-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG11-OH2168540-65-4PROTAC LinkersPROTACPEGlinkerInhibitorinhibitorinhibit

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