MAC glucuronide linker-1

Cat. No.: HY-44221 Purity: 98.56%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MAC glucuronide linker-1 is a claevable ADC linker for antibody-agent-conjugations (ADCs).

For research use only. We do not sell to patients.

MAC glucuronide linker-1 Chemical Structure

CAS No. : 2222981-71-5

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
50 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 4500	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Description

MAC glucuronide linker-1 is a claevable ADC linker for antibody-agent-conjugations (ADCs)^[1].

IC₅₀ & Target

Glycosidase Cleavable Linker

Cleavable Linker

Molecular Weight

897.90

Formula

C₄₂H₄₇N₃O₁₇S

CAS No.

2222981-71-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC)[C@@H](O1)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC2=CC=C(COC(NCCS(=O)(C)=O)=O)C=C2NC(CN(C(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (111.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1137 mL	5.5685 mL	11.1371 mL
5 mM	0.2227 mL	1.1137 mL	2.2274 mL
10 mM	0.1114 mL	0.5569 mL	1.1137 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.56%

Select Batch:

Data Sheet (248 KB) SDS (393 KB)

COA (259 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1137 mL	5.5685 mL	11.1371 mL	27.8427 mL
	5 mM	0.2227 mL	1.1137 mL	2.2274 mL	5.5685 mL
	10 mM	0.1114 mL	0.5569 mL	1.1137 mL	2.7843 mL
	15 mM	0.0742 mL	0.3712 mL	0.7425 mL	1.8562 mL
	20 mM	0.0557 mL	0.2784 mL	0.5569 mL	1.3921 mL
	25 mM	0.0445 mL	0.2227 mL	0.4455 mL	1.1137 mL
	30 mM	0.0371 mL	0.1856 mL	0.3712 mL	0.9281 mL
	40 mM	0.0278 mL	0.1392 mL	0.2784 mL	0.6961 mL
	50 mM	0.0223 mL	0.1114 mL	0.2227 mL	0.5569 mL
	60 mM	0.0186 mL	0.0928 mL	0.1856 mL	0.4640 mL
	80 mM	0.0139 mL	0.0696 mL	0.1392 mL	0.3480 mL
	100 mM	0.0111 mL	0.0557 mL	0.1114 mL	0.2784 mL