Macrophage-activating lipopeptide 2 TFA  (Synonyms: MALP-2 TFA)

Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL)^[1].

Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) can promote the expression of major endothelial adhesion molecules and leukocyte integrin receptors, thereby enhancing leukocyte endothelial adhesion^[1].
Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) can promote the phosphorylation of protein kinase B and eNOS in endothelial MyEnd cells, thereby promoting NO release^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Macrophage-activating lipopeptide 2 (1 µg in 125 µL PBS; once daily; 10 days; i.v.) can improve hind limb perfusion recovery and collateral growth in Apoe deficient mice with experimental femoral artery ligation (FAL) and hypercholesterolemia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2135.56 (free base)

C₉₉H₁₆₇N₁₉O₃₀S.xC₂HF₃O₂

{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys

{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Troidl K, et al. The Lipopeptide MALP-2 Promotes Collateral Growth. Cells. 2020 Apr 16;9(4):997.  [Content Brief]