2. Immunology/Inflammation
  3. CD47
  4. Magrolimab

Magrolimab  (Synonyms: Hu5F9-G4)

Cat. No.: HY-P99029 Purity: 96.40%
COA

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Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of CD47, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer.

For research use only. We do not sell to patients.

CAS No. : 2169232-81-7

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5 mg USD 580 In-stock
10 mg USD 900 In-stock
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Based on 1 publication(s) in Google Scholar

Magrolimab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Magrolimab

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Description

Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of CD47, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer[1][2][3].
Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Chimeric; Humanized

In Vitro

Magrolimab (10 μg/mL, 24 h) can promote the phagocytic activity of tumor associated macrophages towards ovarian or breast tumor cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Magrolimab Related Antibodies
In Vivo

Magrolimab (12-100 μg; once daily; 10 days; i.p.) exhibits anti-tumor activity in mice with Ewing's sarcoma[1].
Magrolimab (250 μg; once every two days; 7 weeks; i.p.) combined with trastuzumab (HY-P9907) can eliminate HER2 positive breast cancer cells in breast cancer mice and overcome the tolerance of trastuzumab[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized and non-humanized ES xenograft NSG-SGM3 mice[1].
Dosage: 12-100 μg
Administration: Intraperitoneal injection (i.p.); once daily; 10 days
Result: Inhibited tumor growth and lung metastasis, and prolonged animal survival time.
Animal Model: 4-8 weeks old NSG female breast cancer mouse model[2].
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.); once every two days; 7 weeks (implanted GFP/luciferase BT474 cells into the left mammary fat pad of female mice)
Result: Restricted the Growth of HER2 ADCC-Tolerant Tumors.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Magrolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Flow cytometry analysis of Jurkat cells labelling CD47 with Magrolimab at 100nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
Purity & Documentation

Purity: 96.40%

COA (291 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Magrolimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magrolimab2169232-81-7Hu5F9-G4CD47Cluster of Differentiation 47MER6OA3antibodybreast cancerbone tumourInhibitorinhibitorinhibit

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