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  3. Drug Derivative
  4. MAIT-203 acetate

MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a Ki value of 0.015 μM and aKd value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells.

For research use only. We do not sell to patients.

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MAIT-203 acetate Chemical Structure

MAIT-203 acetate Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of MAIT-203 acetate:

MAIT-203 acetate Related Antibodies

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Description

MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a Ki value of 0.015 μM and aKd value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells[1].

In Vitro

MAIT-203 (10 μM and 25 μM; for 24 h) acetate reduces Asef-APC interaction in a dose-dependent manner in HEK293T cells[1].
MAIT-203 (10 μM) acetate significantly attenuates SW480 and HCT116 cell migration[1].
Incubation of SW480 cells with MAIT-203 (25, 50 μM;for 24 h) acetate results in a dose-dependent decrease in the amount of the active form of CDC42, but not Rac1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAIT-203 acetate Related Antibodies
Molecular Weight

2517.85 (free base)

Formula

C108H121N43O31
Appearance

Solid

Sequence

Cbz-Ala-Gly-Glu-Ala-{S-3cyclopentylalamine}-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
Sequence Shortening

Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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MAIT-203 acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAIT-203MAIT203MAIT 203Drug DerivativeDrug derivativecyclopentyalanin-derivedAPCAsefInhibitorinhibitorinhibit

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