Mal-Amido-PEG4-Boc

Name: Mal-Amido-PEG4-Boc
Brand: MedChemExpress
SKU: HY-140967
Rating: 4.5 (1 reviews)

Cat. No.: HY-140967 Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-Amido-PEG4-Boc Chemical Structure

CAS No. : 1415800-35-9

Size	Price	Stock	Quantity
100 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

472.53

Formula

C₂₂H₃₆N₂O₉

CAS No.

1415800-35-9

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (423.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1163 mL	10.5813 mL	21.1627 mL
5 mM	0.4233 mL	2.1163 mL	4.2325 mL
10 mM	0.2116 mL	1.0581 mL	2.1163 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (241 KB) HNMR (174 KB) RP-HPLC (224 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1163 mL	10.5813 mL	21.1627 mL	52.9067 mL
	5 mM	0.4233 mL	2.1163 mL	4.2325 mL	10.5813 mL
	10 mM	0.2116 mL	1.0581 mL	2.1163 mL	5.2907 mL
	15 mM	0.1411 mL	0.7054 mL	1.4108 mL	3.5271 mL
	20 mM	0.1058 mL	0.5291 mL	1.0581 mL	2.6453 mL
	25 mM	0.0847 mL	0.4233 mL	0.8465 mL	2.1163 mL
	30 mM	0.0705 mL	0.3527 mL	0.7054 mL	1.7636 mL
	40 mM	0.0529 mL	0.2645 mL	0.5291 mL	1.3227 mL
	50 mM	0.0423 mL	0.2116 mL	0.4233 mL	1.0581 mL
	60 mM	0.0353 mL	0.1764 mL	0.3527 mL	0.8818 mL
	80 mM	0.0265 mL	0.1323 mL	0.2645 mL	0.6613 mL
	100 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.5291 mL