2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mal-C2-NHS ester

Mal-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Mal-C2-NHS ester Chemical Structure

Mal-C2-NHS ester Chemical Structure

CAS No. : 103750-03-4

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Based on 1 publication(s) in Google Scholar

Mal-C2-NHS ester Related Antibodies

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Description

Mal-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Non-cleavable Linker

 

Molecular Weight

294.26

Formula

C13H14N2O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCCCN2C(C=CC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (339.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3984 mL 16.9918 mL 33.9836 mL
5 mM 0.6797 mL 3.3984 mL 6.7967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.30%

COA (250 KB) HNMR (248 KB) LCMS (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3984 mL 16.9918 mL 33.9836 mL 84.9589 mL
5 mM 0.6797 mL 3.3984 mL 6.7967 mL 16.9918 mL
10 mM 0.3398 mL 1.6992 mL 3.3984 mL 8.4959 mL
15 mM 0.2266 mL 1.1328 mL 2.2656 mL 5.6639 mL
20 mM 0.1699 mL 0.8496 mL 1.6992 mL 4.2479 mL
25 mM 0.1359 mL 0.6797 mL 1.3593 mL 3.3984 mL
30 mM 0.1133 mL 0.5664 mL 1.1328 mL 2.8320 mL
40 mM 0.0850 mL 0.4248 mL 0.8496 mL 2.1240 mL
50 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
60 mM 0.0566 mL 0.2832 mL 0.5664 mL 1.4160 mL
80 mM 0.0425 mL 0.2124 mL 0.4248 mL 1.0620 mL
100 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8496 mL
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Mal-C2-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-C2-NHS ester103750-03-4ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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