Mal-(CH2)5-Val-Cit-PAB-Eribulin

Name: Mal-(CH2)5-Val-Cit-PAB-Eribulin
Brand: MedChemExpress
SKU: HY-139642
Rating: 4.5 (1 reviews)

Cat. No.: HY-139642 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-(CH2)5-Val-Cit-PAB-Eribulin is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-microtubule agent, Eribulin, linked via linker Mal-(CH2)5-Val-Cit-PAB.

For research use only. We do not sell to patients.

Mal-(CH2)5-Val-Cit-PAB-Eribulin Chemical Structure

CAS No. : 2130869-21-3

Size	Price	Stock	Quantity
1 mg	USD 392	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1560	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2880	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 8000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-(CH2)5-Val-Cit-PAB-Eribulin is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-microtubule agent, Eribulin, linked via linker Mal-(CH2)5-Val-Cit-PAB^[1].

In Vitro

Eribulin (E7389) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1328.54

Formula

C₆₉H₉₇N₇O₁₉

CAS No.

2130869-21-3

Appearance

Solid

Color

White to yellow

SMILES

C=C1C[C@](O[C@@]1([H])CC[C@](C[C@H]2C)([H])O[C@](C2=C)([H])C[C@@](O[C@@H]3C[C@H](O)CNC(OCC(C=C4)=CC=C4NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN(C5=O)C(C=C5)=O)=O)=O)=O)=O)([H])[C@]([C@H]3OC)([H])CC6=O)([H])CC[C@@]7(C[C@@]8([H])O9)O[C@]([C@](O[C@](C6)([H])CC%10)([H])[C@@]%10([H])O%11)([H])[C@@]9([H])[C@]%11([H])[C@@]8([H])O7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (75.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7527 mL	3.7635 mL	7.5271 mL
5 mM	0.1505 mL	0.7527 mL	1.5054 mL
10 mM	0.0753 mL	0.3764 mL	0.7527 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB) HNMR (242 KB) RP-HPLC (172 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. Patent US20170252458A1.

[2]. Watanabe K, et, al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4; 10(2): 161-174. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7527 mL	3.7635 mL	7.5271 mL	18.8176 mL
	5 mM	0.1505 mL	0.7527 mL	1.5054 mL	3.7635 mL
	10 mM	0.0753 mL	0.3764 mL	0.7527 mL	1.8818 mL
	15 mM	0.0502 mL	0.2509 mL	0.5018 mL	1.2545 mL
	20 mM	0.0376 mL	0.1882 mL	0.3764 mL	0.9409 mL
	25 mM	0.0301 mL	0.1505 mL	0.3011 mL	0.7527 mL
	30 mM	0.0251 mL	0.1255 mL	0.2509 mL	0.6273 mL
	40 mM	0.0188 mL	0.0941 mL	0.1882 mL	0.4704 mL
	50 mM	0.0151 mL	0.0753 mL	0.1505 mL	0.3764 mL
	60 mM	0.0125 mL	0.0627 mL	0.1255 mL	0.3136 mL