2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Mal-PEG1-acid

Mal-PEG1-acid is is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-PEG1-acid Chemical Structure

Mal-PEG1-acid Chemical Structure

CAS No. : 760952-64-5

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25 mg USD 45 In-stock
50 mg USD 75 In-stock
100 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Mal-PEG1-acid Related Antibodies

Top Publications Citing Use of Products

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  • Purity & Documentation

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Description

Mal-PEG1-acid is is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

Non-cleavable Linker

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-PEG1-acid Related Antibodies
Molecular Weight

213.19

Formula

C9H11NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCN1C(C=CC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (469.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6907 mL 23.4533 mL 46.9065 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.40%

COA (247 KB) HNMR (240 KB) LCMS (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6907 mL 23.4533 mL 46.9065 mL 117.2663 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL 23.4533 mL
10 mM 0.4691 mL 2.3453 mL 4.6907 mL 11.7266 mL
15 mM 0.3127 mL 1.5636 mL 3.1271 mL 7.8178 mL
20 mM 0.2345 mL 1.1727 mL 2.3453 mL 5.8633 mL
25 mM 0.1876 mL 0.9381 mL 1.8763 mL 4.6907 mL
30 mM 0.1564 mL 0.7818 mL 1.5636 mL 3.9089 mL
40 mM 0.1173 mL 0.5863 mL 1.1727 mL 2.9317 mL
50 mM 0.0938 mL 0.4691 mL 0.9381 mL 2.3453 mL
60 mM 0.0782 mL 0.3909 mL 0.7818 mL 1.9544 mL
80 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
100 mM 0.0469 mL 0.2345 mL 0.4691 mL 1.1727 mL
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Mal-PEG1-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG1-acid760952-64-5PROTAC LinkersADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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